Medical Microbiology and Immunology

, Volume 159, Issue 4, pp 279–284 | Cite as

Prostaglandins of the E and F series in rabbit cerebrospinal fluid during fever induced by Newcastle disease virus,E. coli-endotoxin, or endogenous Pyrogen

  • W. K. Philipp-Dormston
  • R. Siegert


In rabbit cerebrospinal fluid during fever induced by exogenous or endogenous pyrogens, the concentrations of prostaglandins of the E series are about 2-fold higher in comparison to normal values. In contrast to this the concentrations of prostaglandins of the F series remain unchanged. Prostaglandins of the E group seem to have transmitter functions in genesis of fever during infectious diseases.


Infectious Disease Prostaglandin Cerebrospinal Fluid Disease Virus Newcastle Disease Virus 
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Die Proataglandinkonzentrationen der E-Gruppe im Liquor cerebrospinalis des Kaninchens sind wÄhrend des Fiebers, das durch exogene und endogene Pyrogene induziert wurde, auf das Zweifache gegenüber der Norm erhöht. Demgegenüber bleibt der Gehalt an Prostaglandinen der F-Gruppe unverÄndert. Die Prostaglandine der E-Gruppe scheinen eine Transmitterfunktion in der Genese des Fiebers bei Infektionskrankheiten auszuüben.


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • W. K. Philipp-Dormston
    • 1
  • R. Siegert
    • 1
  1. 1.Hygiene-Institut der UniversitÄt MarburgLahn

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