Medical Microbiology and Immunology

, Volume 159, Issue 4, pp 271–277 | Cite as

Identification of non-specific serum inhibitors of rubella virus haemagglutination

  • Hans Blom
  • Gunnar Haukenes


Different classes of serum lipoproteins were tested for inhibition of the rubella haemagglutinin. In contrast to earlier reports inhibitory activity was demonstrated in all classes, LDL being predominant.

Several data indicate that the inhibitory activity is associated with the polar groups of the phospholipids, exposed at the surface of the lipoprotein.


Inhibitory Activity Early Report Polar Group Rubella Serum Lipoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Auletta, A. E., Gitnick, G. L., Whitmire, C. E., Sever, J. L.: An improved diluent for rubella hemagglutination and hemagglutination inhibition tests. Appl. Microbiol.16, 691–694 (1968)PubMedGoogle Scholar
  2. Burstein, M., Scholnick, H. R.: Precipitation of chylomicrons and very low density lipoproteins from human serum with sodium lamuryl sulphate. Life Sci.11, Part II, 177–184 (1972)CrossRefGoogle Scholar
  3. Burstein, M., Scholnick, H. R., Morfin, R.: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lip. Res.11, 583–595 (1970)Google Scholar
  4. Chang, T. W., Weinstein, L.: Studies of nonspecific inhibition of the hemagglutinin of rubella virus and isolation and identification of the inhibitor. Amer. J. med. Sci.263, 233–239 (1972)PubMedGoogle Scholar
  5. Cooper, L. Z., Matters, B., Rosenblum, J. K., Krugman, S.: Experience with a modified rubella hemagglutination inhibition antibody test. J. Amer. med. Ass.207, 89–93 (1969)Google Scholar
  6. Dyerberg, J., Hjörne, H.: Quantitative plasma lipoprotein estimation by agarose gel electrophoresis. Clin. chim. Acta28, 203–208 (1970)CrossRefPubMedGoogle Scholar
  7. Halonen, P. E., Ryan, J. M., Stewart, J. A.: Rubella hemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells. Proc. Soc. exp. Biol. (N.Y.)125, 162–167 (1967)Google Scholar
  8. Haukenes, G.: A rubella haemagglutination inhibitor simulating antibody. Acta path. microbiol. scand., Sect. B81, 719–723 (1973)Google Scholar
  9. Scanu, A. M., Wisdom, C.: Serum lipoproteins. Structure and function. Ann. Rev. Biochem.41, 703–729 (1972)CrossRefPubMedGoogle Scholar
  10. Sedwick, W. D., Furukawa, T., Plotkin, S. A.: Identification of the serum inhibitor of rubella virus hemagglutination. Bact. Proc.180 (1968)Google Scholar
  11. Shortridge, K. F., Biddle, F.: Rubellavirus nonspecific haemagglutination inhibitor: evidence for the role of glycolipid bound to low density (Β) lipoprotein. Clin. chim. Acta42, 285–294 (1972)CrossRefGoogle Scholar
  12. Smith, I.: Chromatographic electrophoretic techniques, Vol. II, p. 16. London: William Heinemann Medical Books Ltd. 1960Google Scholar
  13. Stewart, G. L., Hamilton, J. P., Meyer, H. M., Jr.: Rubella-virus hemagglutination-inhibition test. New Engl. J. Med.276, 554–557 (1967)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Hans Blom
    • 1
  • Gunnar Haukenes
    • 1
  1. 1.School of Medicine, Gade Institute Department of MicrobiologyUniversity of BergenBergen

Personalised recommendations