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Treatment of LD100 Escherichia coli septic shock with netilmicin and methylprednisolone in baboons

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Abstract

Treatment efficacy with netilmicin sulphate/methylprednisolone sodium succinate in a severe septic shock baboon model, using an LD100 of liveEscherichia coli, was evaluated. All the animals treated with both netilmicin and methylprednisolone were premanent (≥ 7 days) survivors, whereas none of the untreated baboons lived more than 24 hours. These results indicate that, in a baboon model, netilmicin is an effective alternative to gentamicin (with methylprednisolone) in the treatment of severe septic shock.

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Authors and Affiliations

  1. Laboratory Service, Veterans Administration Medical Center, 73104, Oklahoma City, Oklahoma

    D. J. Flournoy

  2. Medical Research, Veterans Administration Medical Center, 73104, Oklahoma City, Oklahoma

    L. T. Archer, B. K. Beller & L. B. Hinshaw

  3. Department of Pathology, University of Oklahoma Health Science Center, 73190, Oklahoma City, Oklahoma, USA

    D. J. Flournoy, L. T. Archer & R. Passey

  4. Department of Physiology and Biophysics, University of Oklahoma Health Science Center, 73190, Oklahoma City, Oklahoma, USA

    B. K. Beller & L. B. Hinshaw

Authors
  1. D. J. Flournoy
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  2. L. T. Archer
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  3. B. K. Beller
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  4. R. Passey
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  5. L. B. Hinshaw
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Flournoy, D.J., Archer, L.T., Beller, B.K. et al. Treatment of LD100 Escherichia coli septic shock with netilmicin and methylprednisolone in baboons. Med Microbiol Immunol 175, 221–227 (1986). https://doi.org/10.1007/BF02123730

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  • DOI: https://doi.org/10.1007/BF02123730

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