Abstract
Biopsies from 9 different oral papillomatous proliferations were analysed for human papilloma viral (HPV) sequences of types 1 to 19 and 21 to 26 by Southern blot analysis with 32p-labelled cellular DNA. HPV sequences were detected in 7 out of 9 biopsies obtained from individual patients. Of three cases with the clinical diagnosis focal hyperplasia Heck, two contained HPV-6 related sequences and one HPV 13. In addition, one tongue base papilloma contained HPV 11. A papilloma of the palate revealed HPV 11 sequences. HPV 6 could be demonstrated twice in the ramaining 4 oral papillomatous proliferations. Two biopsies remained negative. The data shows that HPV DNA can be regularly demonstrated in oral papillomas.
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de Villiers, E.M., Neumann, C., Le, J.Y. et al. Infection of the oral mucosa with defined types of human papillomaviruses. Med Microbiol Immunol 174, 287–294 (1986). https://doi.org/10.1007/BF02123681
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DOI: https://doi.org/10.1007/BF02123681