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Induction of suppressor cells in mice followingVaccinia virus infection

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Abstract

Infection of mice withVaccinia virus produced suppression of responsiveness of spleen cells to mitogens in vitro and suppression of delayed-type hypersensitivity in vivo. The latter suppression was transferred to normal mice by spleen cells of virus-infected mice. The data presented show thatVaccinia virus-induced immunosuppression involves the inductionof suppressor cells which belong to both the adherent and non-adherent cell fractions.

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Authors and Affiliations

  1. Department of Paediatrics, The University of Adelaide, The Adelaide Children's Hospital, 5006, North Adelaide, South Australia

    A. Ferrante, D. E. O'Keefe & Y. H. Thong

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  1. A. Ferrante
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  2. D. E. O'Keefe
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  3. Y. H. Thong
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Ferrante, A., O'Keefe, D.E. & Thong, Y.H. Induction of suppressor cells in mice followingVaccinia virus infection. Med Microbiol Immunol 168, 227–233 (1980). https://doi.org/10.1007/BF02122857

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  • DOI: https://doi.org/10.1007/BF02122857

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