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Medical Microbiology and Immunology

, Volume 165, Issue 2, pp 93–99 | Cite as

Localization of papillomavirus and virus-specific antigens in the skin of tumor-bearingMastomys natalensis (GRA Giessen)

  • Manfred Reinacher
  • Hermann Müller
  • Wolfgang Thiel
  • Roland L. Rudolph
Article

Abstract

In skin neoplasms (so-called keratoakanthomas, papillomas, and squamous cell carcinomas) ofMastomys natalensis (GRA Giessen) virus particles and viral antigens were demonstrated in distinct epithelial layers. Nuclei of the upper parts of the stratum granulosum and disintegrated cell parts of the stratum corneum contain viral structures. The localization of virus particles and viral antigens in any skin neoplasms ofM. natalensis (GRA Giessen) corresponded to the sites where papillomavirus-specific material had been demonstrated in papillomas of other species.

Keywords

Carcinoma Cell Carcinoma Squamous Cell Carcinoma Squamous Cell Virus Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The abbreviations used are

GRA

Giessen-yellow

red-eyed

(gelb, rote Augen) Giessen

MnPV

Mastomys natalensis papillomavirus

IgG

immunoglobulin G

kV

kilovolt

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References

  1. Burtscher, H., Grünberg, W., Meingassner, G.: Infektiöse Keratoakanthome der Epidermis bei Praomys (Mastomys) natalensis. Naturwissenschaften,60, 209–210 (1973)Google Scholar
  2. Müller, H., Gissmann, L.: Mastomys natalensis papilloma virus (MnPV), the causative agent of epithelial proliferations: characterization of the virus particle. J. Gen. Virol., (in press, 1978)Google Scholar
  3. Rudolph, R.L., Hundeiker, M.: “Keratoakanthome bei Mastomys natalensis. Arch. Dermatol. Res.,254, 239–243 (1975)PubMedGoogle Scholar
  4. Rudolph, R.L., Müller, H.: Induktion von epidermalem Tumorwachstum in der Haut von Mastomys natalensis durch Übertragung virushaltigen Tumorgewebes eines Plattenepithelkarzinoms. Zentralbl. Veterinaermed. [B],23, 143–150 (1976)Google Scholar
  5. Rudolph, R.I., Thiel, W.: Pathologische Anatomie und Histologie von spontanen, epithelialen Hauttumoren bei Mastomys natalensis. Zentralbl. Veterinaermed. [A],23, 429–441 (1976)Google Scholar
  6. Venable, J.H., Coggeshall, R.: A simplified lead citrate stain for use in electron microscopy. J. Cell Biol.25, 407–408 (1965)PubMedGoogle Scholar
  7. zur Hausen, H.: Human papillomaviruses and their possible role in squamous cell carcinomas. Curr. Top. Microbiol. Immunol.78, 1–30 (1977)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Manfred Reinacher
    • 1
    • 2
  • Hermann Müller
    • 1
    • 2
  • Wolfgang Thiel
    • 1
    • 2
  • Roland L. Rudolph
    • 1
    • 2
  1. 1.Veterinär-Pathologisches InstitutJustus-Liebig-Universität GiessenGiessenGermany
  2. 2.Institut für VirologieJustus-Liebig-Universität GiessenGiessenGermany

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