Antigenic relationship between the surface antigens of avian and Equine influenza viruses
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Influenza virus Equine 1 (A/equine/Prague/56) has a hemagglutinin which is antigenically related to the hemagglutinin of fowl plague virus strain Rostock (FPV) and a neuraminidase which cross-reacts with the enzyme of virus N (A/chick/Germany/49). After a single injection of chickens with Equine 1 virus no hemagglutination inhibiting (HI) and neutralizing antibodies against FPV can be demonstrated, although the birds are fully protected against a lethal dose of FPV. HI and neutralizing antibodies against FPV appear after a second injection of Equine 1 virus several weeks after the first one. Liberation of newly synthesized FPV from the host cell is inhibited by antibodies cross-reacting with any antigen of the virus surface.
KeywordsInfluenza Host Cell Influenza Virus Surface Antigen Virus Strain
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- Cunningham, C. H.: A laboratory guide in virology, p. 88. Minneapolis, Minnesota: Burgess 1960Google Scholar
- Drzeniek, R., Seto, J. T., Rott, R.: Characterization of neuraminidase from myxoviruses. Biochem. biophys. Acta (Amst.)128, 547–558 (1966)Google Scholar
- Reed, L. J., Muench, H.: A simple method of estimating fifty per cent endpoints. Amer. J. Hyg. 493–497 (1938)Google Scholar
- Schäfer, W., Zimmermann, T., Schuster, H.: Inaktivierung verschiedener menschen- und tierpathogener Virusarten sowie des Tabak-Mosaik-Virus durch salpetrige Säure. Z. Naturforsch.14b, 632–641 (1959)Google Scholar
- Tumova, B., Schild, G. C.: Antigenic relationship between type A influenzaviruses of human, porcine, equine, and avian origin. Bull. Wld. Hlth. Org.47, 453–460 (1972)Google Scholar
- W. H. O. Report: A revised system of nomenclature for influenza viruses. Bull. Wld. Hlth. Org.45, 119–124 (1971)Google Scholar