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Failure of rescue between influenza a viruses

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Summary

There is no rescue between two influenza A virus strains or variants, if the multiplication of the superinfecting virus is prevented by simultaneous infection with vesicular stomatitis virus or by actinomycin D. The results are discussed in terms of the unability of the RNA polymerase of one strain to use the RNA of the other strain as template.

Zusammenfassung

Restaurierung zwischen zwei Influenza A-Stämmen oder Varianten ist nicht möglich, wenn die Vermehrung des zweitinfizierenden Virus durch gleichzeitige Infektion mit dem Virus der vesiculären Stomatitis oder durch Actinomycin D verhindert wird. Als Erklärung wird angenommen, daß die RNS-Polymerase des einen Stammes die RNS des zweitinfizierenden Stammes nicht als Matrize benutzen kann.

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Schwarz, R., Scholtissek, C. & Rott, R. Failure of rescue between influenza a viruses. Med Microbiol Immunol 158, 54–57 (1972). https://doi.org/10.1007/BF02122008

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  • DOI: https://doi.org/10.1007/BF02122008

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