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Medical Microbiology and Immunology

, Volume 168, Issue 2, pp 103–110 | Cite as

Phosphorylation of myelin basic protein by vaccinia virus

  • R. Tschannen
  • A. J. Steck
  • R. Schäfer
Original Investigations

Abstract

Vaccinia virus phosphorylates myelin basic protein in the myelin membrane in vitro. In the presence of vaccinia virus cores maximally 1.5 mol and in the presence of intact virus 0.7 mol phosphate residues were incorporated into 1 mol of myelin basic protein in the myelin membrane. The peptides of myelin basic protein which were phosphorylated by the vaccinia virus kinase were clearly all different from the peptides which were phosphorylated by the endogenous myelin protein kinase.

The viral modification of the encephalitogenic protein and its significance to immunological events is discussed.

Keywords

Peptide Phosphate Protein Kinase Myelin Basic Protein Vaccinia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • R. Tschannen
    • 1
  • A. J. Steck
    • 2
  • R. Schäfer
    • 1
  1. 1.Department of Structure Biology, BiozentrumUniversity of BaselBaselSwitzerland
  2. 2.Department of NeurologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

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