Immunosuppression by measles virus
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In 1908 Von Pirquet noted that during a measles virus infection, but before the onset of the rash, former positive skintests (PPD) were negative. Since then this has in vivo been confirmed by many investigators. More recent experiments on the in vivo effects of measles virus on lymphocyte activities have yielded conflicting results. It will be shown that it might be essential to use purified measles virus to obtain interpretable data.
Results obtained by infecting lymphocytes with purified measles virus on their subsequent stimulation by mitogen or antigen will be given.