Medical Microbiology and Immunology

, Volume 160, Issue 4, pp 295–309 | Cite as

The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection

  • R. Jennings
  • C. M. Brand
  • C. McLaren
  • Lynda Shepherd
  • C. W. Potter
Article

Abstract

The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.

Keywords

Immune Response Influenza Virus Infection Influenza Virus Antibody Response 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • R. Jennings
    • 1
  • C. M. Brand
    • 1
    • 2
  • C. McLaren
    • 1
  • Lynda Shepherd
    • 1
  • C. W. Potter
    • 1
  1. 1.Academic Division of PathologyUniversity of SheffieldSheffield
  2. 2.Wellcome Research LaboratoriesBeckenhamEngland

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