Medical Microbiology and Immunology

, Volume 162, Issue 2, pp 153–158 | Cite as

Supression of growth ofVibrio cholerae in the intestine of immunized mice

  • Jürgen Knop
  • J. E. C. Bellamy


In ligated intestinal loops of actively immunized adult mice, growth ofV. cholerae 569B was suppressed approximately seven fold when compared to bacterial growth in non-immune animals. Similarly, growth ofV. choleare 569B was reduced in mice immunized with a hybrid vibrio strain, NCV569B-165, which shares only flagella antigens withV. cholerae 569B. Immunofluorescence studies of intestinal loop contents and intestinal sections indicated that, in non-immune mice, vibrios coated the intestinal mucosa. In contrast, the intestinal mucosa of immune animals was almost free of bacteria. The vibrios were found agglutinated in the intestinal lumen contents of immune animals. It was concluded that immunization suppressed the growth ofV. cholerae in the intestinal lumen and the possibility that bacterial agglutination mediates this growth suppression is discussed.


Growth Suppression Bacterial Growth Adult Mouse Intestinal Mucosa Intestinal Lumen 
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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Jürgen Knop
    • 1
    • 2
  • J. E. C. Bellamy
    • 1
  1. 1.Department of MicrobiologyUniversity of AdelaideAdelaideAustralia
  2. 2.Hautklinik der Westfälischen Wilhelms-UniversitätMünsterFederal Republic of Germany

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