Abstract
Mesenchymal and epithelial human malignancies were examined in the simultaneous detection test for the presence of particles with 70 S RNA and reverse transcriptase. Out of the 23 tumors tested 14 were found to be positive (61%). The finding that 2 uterine cancers contained 70 S RNA and reverse transcriptase indicates that uterine cancers may belong to the list of malignancies where the involvement of oncornaviruses is suspected. Out of the 10 human sarcomas examined in this study 4 were shown to contain particles with properties of oncornaviruses.
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Axel, R., Gulati, S. C., Spiegelman, S.: Particles containing RNA-instructed DNA polymerase and virusrelated RNA in human breast cancers. Proc. nat. Acad. Sci. (Wash.)69, 3133–3137 (1972)
Baxt, W., Hehlmann, R., Spiegelman, S.: Human leukemic cells contain reverse transcriptase associated with a high molecular weight virus-related RNA. Nature New Biol.240, 72–75 (1972)
Birkmayer, G. D., Miller, F., Marguth, F.: Oncorna-viral information in human glioblastoma. J. Neural. Transm.35, 251–254 (1974)
Cuatico, W., Cho, J.-R., Spiegelman, S.: Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors. Proc. nat. Acad. Sci. (Wash.)70, 2789–2793 (1973)
Cuatico, W., Cho, J.-R., Spiegelman, S.: Evidence of particle-associated RNA-directed DNA polymerase and high molecular weight RNA in human gastrointestinal and lung malignancies. Proc. nat. Acad. Sci. (Wash.)71, 3304–3308 (1974)
Gallagher, R. E., Gallo, R. C.: Type C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells. Science187, 350–353 (1975)
Gillespie, D., Marshall, S., Gallo, R. C.: RNA of RNA tumour viruses contains poly A. Nature New Biol.236, 272 (1972)
Jensik, S., Hoekstra, J., Silver, S., Northrop, R. L., Deinhardt, F.: The 60 to 70 S RNA and reverse transcriptase of simian sarcoma and simian sarcoma-associated virus. Intervirology1, 229–241 (1973)
Kufe, D., Hehlmann, R., Spiegelman, S.: Human sarcomas contain RNA related to the RNA of a mouse leukemia virus. Science175, 182–185 (1971)
Kufe, D., Magrath, I. T., Ziegler, J. L., Spiegelman, S.: Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA. Proc. nat. Acad. Sci. (Wash.)70, 737–741 (1973)
Laufs, R., Steinke, H.: No evidence for particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA in Herpesvirus induced tumors of nonhuman primates. J. gen. Virol.27, 239–245 (1975)
Schlom, J., Spiegelman, S.: Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. Science174, 840–843 (1971)
Temin, H. M.: The cellular and molecular biology of RNA tumor viruses, especially avian leukosis-sarcoma viruses, and their relatives. In: Advances in Cancer Research, Vol. 19 (G. Klein and S. Weinhouse, eds.), pp. 48–96. New York-London: Academic Press 1974
Theilen, G. H., Gould, D., Fowler, M., Dungworth, D. L.: C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. J. nat. Cancer Inst.47, 881–889 (1971)
Wolfe, L. G., Smith, R. K., Deinhardt, F.: Simian sarcoma virus, type 1 (Lagothrix): Focus assay and demonstration of nontransforming associated virus. J. nat. Cancer Inst.48, 1905–1908 (1972)
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This study was supported by the Deutsche Forschungsgemeinschaft, D-5300 Bad Godesberg.
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Steinke, H., Laufs, R. & Dörfler, W. Oncornaviruslike particles in human malignancies. Med Microbiol Immunol 162, 137–142 (1976). https://doi.org/10.1007/BF02121323
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DOI: https://doi.org/10.1007/BF02121323