Abstract
The viruses of the Kemerovo complex, genusOrbivirus, family Reoviridae, are widely distributed in the habitats ofIxodes ticks in Eurasia. Their incidence in ticks sometimes surpasses that of the tick-borne encephalitis virus (TEV).
Neutralizing antibodies in serum of healthy residents in natural foci indicate contact with Kemerovo complex viruses in 8.5–18.0%. Kemerovo complex viruses were isolated from the cerebrospinal fluid of patients with meningitis and tick-borne encephalitis.
Serological studies in neurological patients from Central Europe were carried out with the Lipovník virus (LV) serotype. Of patients from Ostrava district with confirmed tick-borne encephalitis 51% revealed concurrent neutralizing antibody response to LV. Of 36 patients from Graz district who had neutralizing antibodies to TEV in the cerebrospinal fluid (CSF), 72.5% also had CSF-LV antibodies. This finding supports the importance of concurrent LV-infection in the development of overt TE. Patients from Bratislava Region with abacterial meningitis, polyradiculoneuritis, and multiple sclerosis (MS) had LV-serum antibodies in 50%, 41.2%, and 45.2% of cases, respectively. This is a significantly higher incidence than in the control groups (P=0.05). Of MS patients 53% had LV-antibodies also in the CSF, often in combination with measles and herpes simplex type 1 virus antibodies. The relationship of LV to the etiology and course of chronic neurological diseases remains to be elucidated.
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Libíková, H., Heinz, F., Ujházyová, D. et al. Orbiviruses of the Kemerovo complex and neurological diseases. Med Microbiol Immunol 166, 255–263 (1978). https://doi.org/10.1007/BF02121159
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DOI: https://doi.org/10.1007/BF02121159