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Growth of some attenuated influenza A viruses in hamsters

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Abstract

The replication of three attenuated influenza viruses in SPF hamsters inoculated by aerosol was investigated. Strains A2-Eng, A2-Victoria, ts-1-[E] A2-Victoria recombinant, and the RIT 4050 strain all multiplied to high liters in hamster lungs and induced both primary and secondary serological responses. Recombinant strain, A/AA/6/60-A2-Vic (CR22) multiplied to lower titers in hamsters. Differences were observed between the infectivity of different strains for hamsters, the wild-type viruses A2-Eng and A2-Vic being the most infective.

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  1. Sandoz Forschungsinstitut, Wien, Austria

    P. Reeve

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  1. P. Reeve
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Reeve, P. Growth of some attenuated influenza A viruses in hamsters. Med Microbiol Immunol 166, 133–139 (1978). https://doi.org/10.1007/BF02121142

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  • DOI: https://doi.org/10.1007/BF02121142

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