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Medical Microbiology and Immunology

, Volume 166, Issue 1–4, pp 91–98 | Cite as

Trials of live influenza A recombinants in man during natural antigenic change in 1971–1976

  • A. S. Beare
  • A. P. Kendal
  • G. C. Schild
Article

Abstract

A long-term study is described of human trials with live recombinants derived from A/PR/8/34 (H0 N1) and successive virulent H3 N2 viruses. A/ PR/8/34 was noninfectious for man and the H3 N2 strains all induced similar influenza-like illness. In each recombinant experiment, some of the progeny were adequately attenuated and potentially immunogenic. In addition, there appeared to be evidence of probable cross-protection against viruses with related but non-identical haemagglutinins. However, the degree of cross-protection depended upon the time interval between the appearance of the epidemic and vaccine viruses. Recombinants of A/PR/8/34 and a human Hsw1 strain of low virulence did not function satisfactorily, and it seemed that the suitability of A/PR/8/34 as a ‘master’ parent depended upon the presence of standard genetic properties in the wild parents. The replacement of A/PR/8/34 with the partially virulent virus, X-31 (H3 N2), produced a live vaccine which was infectious but poorly antigenic. A universal master strain for live influenza vaccine recombinants is probably not yet a practical possibility.

Keywords

Influenza Influenza Vaccine Vaccine Recombinant Live Vaccine Genetic Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • A. S. Beare
    • 1
  • A. P. Kendal
    • 2
  • G. C. Schild
    • 3
  1. 1.MRC Common Cold UnitUK
  2. 2.Center for Disease ControlAtlantaUSA
  3. 3.National Institute for Biological Standards and ControlLondonUK

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