Trials of live influenza A recombinants in man during natural antigenic change in 1971–1976
- 25 Downloads
A long-term study is described of human trials with live recombinants derived from A/PR/8/34 (H0 N1) and successive virulent H3 N2 viruses. A/ PR/8/34 was noninfectious for man and the H3 N2 strains all induced similar influenza-like illness. In each recombinant experiment, some of the progeny were adequately attenuated and potentially immunogenic. In addition, there appeared to be evidence of probable cross-protection against viruses with related but non-identical haemagglutinins. However, the degree of cross-protection depended upon the time interval between the appearance of the epidemic and vaccine viruses. Recombinants of A/PR/8/34 and a human Hsw1 strain of low virulence did not function satisfactorily, and it seemed that the suitability of A/PR/8/34 as a ‘master’ parent depended upon the presence of standard genetic properties in the wild parents. The replacement of A/PR/8/34 with the partially virulent virus, X-31 (H3 N2), produced a live vaccine which was infectious but poorly antigenic. A universal master strain for live influenza vaccine recombinants is probably not yet a practical possibility.
KeywordsInfluenza Influenza Vaccine Vaccine Recombinant Live Vaccine Genetic Property
Unable to display preview. Download preview PDF.
- Beare, A.S.: Live viruses for immunization against influenza. Progr. Med. Virol.20, 49–83 (1975)Google Scholar
- Beare, A.S., Craig, J.W.: Virulence for man of a human influenza-A virus antigenically similar to “classical” swine viruses. Lancet1976 II, 4–5Google Scholar
- Beare, A.S., Hall, T.S.: Recombinant influenza-A viruses as live vaccines for man. Lancet1971 II, 1271–1273Google Scholar
- Beare, A.S., Reed, S.E.: The study of antiviral compounds in volunteers. In: Chemoprophylaxis and virus infections of the respiratory tractII, pp. 27–55. (ed. J.S. Oxford. Cleveland, Ohio: CRC Press 1977Google Scholar
- Beare, A.S., Schild, G.C., Craig, J.W.: Trials in man with live recombinants made from A/PR/8/34 (H0 N1) and wild H3 N2 influenza viruses. Lancet1975 II, 729–732Google Scholar
- Center for Disease Control: Morbidity and mortality weekly report25, 391 (1976)Google Scholar
- Florent, G., Lobmann, M., Beare, A.S., Zygraich, N.: RNAs of influenza virus recombinants derived from parents of known virulence for man. Arch. of Virol.54, 19–28 (1977)Google Scholar
- Oxford, J.S., McGeoch, D., Schild, G.C., Beare, A.S.: Influenza A virus recombinants of defined virulence for man: Differences in virus RNA, polypeptides, and typespecific NP antigen. In: Negative Strand Viruses and the Host Cell (eds. B.W.J. Mahy and R.D. Barry). London, New York: Academic Press. In the pressGoogle Scholar
- Schulman, J.L., Palese, P.: Genes influencing biological properties of influenza A viruses. In: Negative Strand Viruses and the Host Cell (eds. B.W.J. Mahy and R.D. Barry). London; New York: Academic Press (1977)Google Scholar