Abstract
The model of genetic susceptibility to poliomyelitis has been used to examine minor illness caused by poliovirus infection. It is suggested that persons who are genetically susceptible but who have not converted to phenotypic susceptibility are those who develop minor illness. The overall rates of the sum of paralytic and minor illness are close to the predicted 26%. For families with a case of illness, the prediction that 58%–71% of the children become ill has been examined. The rates of illness in children of different ages in the same families should be similar. Data from a number of epidemics is shown to be consistent with the predictions of the model.
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Paul, J.R.: The epidemiology of poliomyelitis. In: Poliomyelitis. WHO Monograph SeriesNo. 26 Geneva (1955)
Wyatt, H.V.: Is poliomyelitis a genetically-determined disease? I: A genetic model. Med. Hypotheses1, 35–42 (1975)
Wyatt, H.V.: Is poliomyelitis an auto-allergic disease triggered by virus? Med. Hypotheses2, 262–268 (1976)
Wyatt, H.V.: Provocation poliomyelitis and entry of poliovirus to the CNS. Med. Hypotheses2, 269–274 (1976)
Wyatt, H.V.: Is poliomyelitis a genetically-determined disease? II: A critical examination of the epidemiological data. Med. Hypotheses1, 87–96 (1975)
Gelfand, H.M., Leblanc, D.R., Fox, J.P., Conwell, D.P.: Studies on the development of natural immunity to poliomyelitis in Louisiana. II: Description and analysis of episodes of infection observed in study group households. Am. J. Hyg.65, 367–385 (1957)
Nathanson, N., Langmuir, A.D.: The Cutter Incident. II: The relationship of poliomyelitis to Cutter vaccine. Am. J. Hyg.78, 29–69 (1963)
Wickman, I.:Acute Poliomyelitis. Nervous and Mental Diseases Monograph SeriesNo. 16 (English translation). 1913 Also Johnson Reprint Corporation 1970
Pearson, H.E., Brown, G.C., Rendtorff, R.C., Ridenour, G.M., Francis, T.: Studies of the distribution of poliomyelitis virus. III: In an urban area during an epidemic. Am. J. Hyg.41, 188–210 (1945)
Perkins, J.E.: Apparent spread of poliomyelitis through families. Minn. Med.24, 924–933 (1941)
Nolan, J.P., Wilmer, B.H., Melrick, J.L.: Poliomyelitis: its highly invasive nature and narrow stream of infection in a community of high socioeconomic level. New Engl. J. Med.253, 945–954 (1955)
Horstmann, D.M., McCollum, R.W., Mascola, A.D.: The incidence of infection among contacts of poliomyelitis cases. J. Clin. Invest.34, 1573–1580 (1955)
Paul, J.R., Salinger, R., Trask, J.D.: Studies on the epidemiology of poliomyelitis II. The incidence of abortive types of poliomyelitis. Am. J. Hyg.17, 601–612 (1933)
Paul, J.R., Salinger, R., Trask, J.D.: “Abortive” poliomyelitis. J.A.M.A.98, 2262–2268 (1932)
McClure, G.Y., Langmuir, A.D.: Search for carriers in an outbreak of acute anterior poliomyelitis in a rural community. The incidence of virus in faeces. Am. J. Hyg.35, 285–291 (1942)
Bodian, D., Paffenbarger, R.S.: Poliomyelitis infection in households. Frequency of viremia and specific antibody response. Am. J. Hyg.60, 83–98 (1954)
International Committee.Infantile Paralysis, Table 41 p. 367. Baltimore: Williams and Wilkins 1932
Horstmann, D.M.: The clinical epidemiology of poliomyelitis. Ann. Int. Med.43, 526–533 (1955)
Paul, J.R., Salinger, R., Trask, J.D.: Studies on the epidemiology of poliomyelitis. I: Methods and criteria for the detection of abortive poliomyelitis. Am. J. Hyg.17, 587–600 (1933)
Shidler, G.P.: The epidemic of spinal disease in Nebraska. J.A.M.A.54, 277–281 (1910)
Eklund, C.M., Larson, C.L.: Outbreak of Type 3 poliomyelitis on St. Paul Island, Alaska. Am. J. Hyg.63, 115–126 (1956)
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Wyatt, H.V. Abortive poliomyelitis or minor illness as a clue to genetic susceptibility. Med Microbiol Immunol 166, 29–36 (1978). https://doi.org/10.1007/BF02121131
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DOI: https://doi.org/10.1007/BF02121131