Cardiac Arrhythmias Provoked by Focal Application of Delphinine
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Delphinine, focally applied on the atria of the exposed heart of the dog, elicits atrial flutter persisting long enough to permit studies of this arrhythmia. Vagus stimulation increased the rate of the flutter. In some experiments when the flutter subsided or before it started, tachycardias were observed which were terminated suddenly by vagus stimulation and re-appeared also suddenly and must therefore be termed paroxysmal tachycardias.
Mechanical pressure exerted on the focus on which delphinine had been applied caused atrial fibrillation which disappeared quickly after pressure was discontinued.
Ligation across any possible pathway around the venae cavae did not influence existing flutter and fibrillation. Cooling of the focus of application or clamping it from the rest of the atria stopped the flutter immediately.
Delphinine is an excellent means to create experimentally atrial flutter or ventricular paroxysmal tachycardia orginating in a focus of rapid impulse formation.
KeywordsPublic Health Atrial Fibrillation Cardiac Arrhythmia Vagus Stimulation Atrial Flutter
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