Experientia

, Volume 42, Issue 4, pp 389–390 | Cite as

Cadmium-induced changes in renal hemodynamics in the domestic fowl

  • D. N. Prashad
  • E. A. Hawkins
  • R. Blackburn
  • J. Haslam
Short Communications

Summary

Low i.v. doses of cadmium chloride (15 μg Cd) given to pullets resulted in a significant reduction in urine flow (UF), glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). However, in hens treated with the heavy metal chelate FeNa EDTA prior to cadmium treatment no oliguria or reduction in GFR or ERPF was observed.

It is suggested that the renal changes following the i. v. administration of cadmium to diuretic hens and alleviated in hens primed with the heavy metal chelate may result from changes in glomerular hemodynamics.

Key words

Glomerular filtration rate effective renal plasma flow FeNa EDTA chelate 

References

  1. 1.
    Yost, K.J., Experientia40 (1984) 157.CrossRefPubMedGoogle Scholar
  2. 2.
    Pitts, F.R., in: Physiology of kidney and body fluids, 3rd edn, p. 158. Yr. Bk. Med. Publ. (1974).Google Scholar
  3. 3.
    Sturkie, P.D., in: Avian Physiology, 3rd edn, p. 76. Springer-Verlag, Berlin 1976.Google Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • D. N. Prashad
    • 1
    • 2
  • E. A. Hawkins
    • 1
    • 2
  • R. Blackburn
    • 1
    • 2
  • J. Haslam
    • 1
    • 2
  1. 1.Thames PolytechnicSchool of Biological Sciences and Environmental HealthLondon(England)
  2. 2.Chelsea CollegeUniversity of LondonLondon(England)

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