Experientia

, Volume 48, Issue 9, pp 882–885 | Cite as

Antifungal properties of taxol and various analogues

  • D. H. Young
  • E. L. Michelotti
  • C. S. Swindell
  • N. E. Krauss
Research Articles

Abstract

The antimitotic agent taxol was tested for toxicity towards fungi from different taxonomic groups and found to be particularly active against oomycete fungi. In germinating zoospore cysts of the oomycetePhytophthora capsici the mechanism of action of taxol was shown to involve inhibition of mitosis, presumably resulting from an effect on microtubules. Various taxol analogues with deleted A-ring C-13 side chain substituents were tested for toxicity towardsP. capsici andAphanomyces cochlioides to provide insight into structural features required for activity. The importance of the side chain was shown by the much lower activity as compared to taxol of analogues lacking all or part of the side chain. The effect of stereochemistry at the C-2′ position on fungitoxicity towards oomycetes was similar to that reported previously on mammalian microtubule assembly.

Key words

Taxol antifungal Phytophthora capsici nuclear division microtubules 

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • D. H. Young
    • 1
  • E. L. Michelotti
    • 1
  • C. S. Swindell
    • 2
  • N. E. Krauss
    • 2
  1. 1.Research LaboratoriesRohm and Haas Co.Spring HouseUSA
  2. 2.Department of ChemistryBryn Mawr CollegeBryn MawrUSA

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