Journal of Radioanalytical and Nuclear Chemistry

, Volume 109, Issue 1, pp 89–100 | Cite as

Trace elements in skin epitheliomas

  • V. Papassotiriou
  • S. Georgala
  • J. Stratigos
  • N. Panayotakis
  • A. Hadjiantoniou
  • A. A. Katsanos


Skin tissue samples from 41 patients suffering from skin epitheliomas were analyzed by the PIXE method. Skin samples from the non-affected areas and blood serum were also analyzed for the same patients. The elements determined were K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Br, Rb, and Pb. Their concentrations in the healthy skin and the serum were normal. The concentrations in the lesions were nearly the same for both basal cell and squamus cell epitheliomas (BCE and SCC) except for higher zinc and lower bromine values in the BCE samples. However, substantial differences were observed between the affected and non-affected skin.


Zinc Inorganic Chemistry Tissue Sample Squamus Cell Basal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    I. H. TIPTON, M. J. COOK, R. L. STEINER, C. A. BOYE, H. M. PERRY JR., H. A. SCHROEDER, Health Phys., 9 (1963) 89.PubMedGoogle Scholar
  2. 2.
    I. H. TIPTON, M. J. COOK, Health Phys., 9 (1963) 103.PubMedGoogle Scholar
  3. 3.
    Elemental Analysis of Biological Materials, Techn. Report Ser. 197, IAEA, Vienna, 1980.Google Scholar
  4. 4.
    G. V. IYENGAR, W. E. KOLLMER, H. J. M. BOWEN, The Elemental Composition of Human Tissues and Body Fluids, Verlag Chemie-Weinheim, New York, 1978.Google Scholar
  5. 5.
    S. D. SOMAN, K. T. JOSEPH, S. J. RAUT, C. D. MULAY, M. PARAMESHWARAN, V. K. PANDAY, Health Phys., 19 (1970) 641.PubMedGoogle Scholar
  6. 6.
    E. I. HAMILTON, M. J. MINSKI, J. J. CLEARY, Sci. Total Environ., 1 (1972) 341.Google Scholar
  7. 7.
    G. F. CLEMENTE, L. GIGNA ROSSI, G. P. SANTARONI, J. Radioanal. Chem., 37 (1977) 549.Google Scholar
  8. 8.
    A. A. KATSANOS, Proc. Intern. Symp. on Nuclear Activation Technique in Life Sciences, Vienna, 22–26 May 1978, paper No 103.Google Scholar
  9. 9.
    L. S. HURLEY, Fed. Proc., 35 (1976) 2271.PubMedGoogle Scholar
  10. 10.
    J. F. RIORDAN, Med. Clin. North Amer., 60 (1976) 871.Google Scholar
  11. 11.
    B. L. O'DELL, Med. Clin. North Amer., 60 (1976) 907.Google Scholar
  12. 12.
    R. I. HENKIN, Med. Clin. North Amer., 60 (1976) 1023.Google Scholar
  13. 13.
    W. MERTZ, Science, 213 (1981) 1332.PubMedGoogle Scholar
  14. 14.
    B. PAPASSOTIRIOU, Trace Elements Concentration Study in Skin Tumors, Ph. D. Thesis, Athens, 1984 (in Greek).Google Scholar
  15. 15.
    A. MOLOKHIS, B. PORTNOY, A. DYER, Brit. J. Derm., 101 (1979) 567.PubMedGoogle Scholar
  16. 16.
    K. G. MALMQVIST, L. E. CARLSSON, B. FORSLIND, G. M. ROOMANS, K. R. AKSELSSON, Nucl. Instr. Meth., B3 (1984) 611.Google Scholar
  17. 17.
    J. A. KAPETANAKIS, Dermatology, Parissianos G. K., Athens, 1969 (in Greek).Google Scholar
  18. 18.
    A. KATSANOS, A. XENOULIS, A. HADJIANTONIOU, R. W. FINK, Nucl. Instr. Methods, 137 (1976) 119.Google Scholar
  19. 19.
    A. A. KATSANOS, Elemental X-ray Microanalysis by Charged Particle Excitation with Application to Local Problems, Report IAEA Contract No. 1608/RB, 1975.Google Scholar
  20. 20.
    S. A. E. JOHANSSON, T. B. JOHANSSON, Nucl. Instr. Methods, 137 (1976) 473.Google Scholar
  21. 21.
    W. HUDA, D. K. BEWLEY, Phys. Meth. Biol., 24 (1979) 711.Google Scholar
  22. 22.
    R. L. WALTER, R. D. WILLIS, W. F. GUTKNECHT, R. W. SHAW, Nucl. Instr. Methods, 142 (1977) 181.Google Scholar
  23. 23.
    A. A. KATSANOS, Trace Elements Analysis, IAEA Report No. 1488, 1979.Google Scholar
  24. 24.
    R. L. WATSON, J. A. DEMAREST, A. LANGEBERG, F. E. JENSON, J. R. WHITE, C. C. BAHR, IEEE Trans. Nucl. Sci., 26 (1979) 1352.Google Scholar
  25. 25.
    V. VALCOVIC, Nucl. Instr. Methods, 142 (1977) 151.Google Scholar
  26. 26.
    J. L. CAMBELL, IEEE Trans. Nucl. Sci., 26 (1979) 1363.Google Scholar
  27. 27.
    I. HASSELMANN, W. KOENIG, F. W. RICHTER, U. STEINER, U. WATJEN, J. C. BODE, W. OHTA, Nucl. Instr. Methods, 142 (1977) 163.Google Scholar
  28. 28.
    J. L. CAMBELL, S. B. RUSSEL, S. FAIG, C. W. SCHULTE, R. W. OLLERHEAD, R. R. GINGERICH, Nucl. Instr. Methods, 181 (1981) 285.Google Scholar
  29. 29.
    T. A. CAHILL, Ann. Rev. Nucl. Part. Sci., 30 (1980) 211.Google Scholar
  30. 30.
    A. KATSANOS, A. HADJIANTONIOU, Nucl. Instr. Methods, 149 (1978) 469.Google Scholar
  31. 31.
    A. H. KHAN, M. KHALIQUZZAMAN, M. B. ZAMAN, M. HUSAIN, M. ABDULLAH, S. AKHTER, J. Radioanal. Chem., 57 (1980) 157.Google Scholar
  32. 32.
    P. K. KAKANIS, A. A. KATSANOS, Nucl. Instr. Methods, B3 (1984) 311.Google Scholar
  33. 33.
    G. DECONNICK, F. BODART, E. DEMOULIN, Nucl. Instr. Methods, 181 (1981) 259.Google Scholar
  34. 34.
    I. STRATIGOS, Contribution to the Study of Carcinogenic Effect of the Solar Radiation in Skin, Ph. D. Thesis, Athens, 1968 (in Greek).Google Scholar
  35. 35.
    I. J. T. DAVIES, M. MUSA, T. L. DORMANDY, J. Clin. Path., 21 (1968) 359.PubMedGoogle Scholar
  36. 36.
    L. MING-CHIEN, T. MING-GUANG, C. JUN-FA, S. KANG-lONG, C. ZHI-XIANG, C. JIA-HUA, Z. WEN, L. WEI-LI, X. ZONG-GIN, K. AN-KUN, Nucl. Instr. Methods, 181 (1981) 309.Google Scholar
  37. 37.
    M. BERTI, G. BUSO, P. COLAUTTI, G. MOSCHINI, B. M. STIEVANO, C. TREGNAGHI, Anal. Chem., 49 (1973) 1313.Google Scholar
  38. 38.
    A. A. KATSANOS, A. HADJIANTONIOU, N. PANAYIOTAKIS, M. TZOUMEZI, Health Related Monitoring of Trace Elements by PIXE, IAEA-TECDOC 330, 1985, p. 67.Google Scholar
  39. 39.
    T. PARADELLIS, N. PANAYIOTAKIS, J. Radioanal. Chem., 59 (1980) 221.Google Scholar
  40. 40.
    I. L. MULAY, R. ROY, B. E. KNOX, N. H. SUHR, W. E. DELANEY, J. Nat. Cancer Inst., 47 (1971) 1.PubMedGoogle Scholar
  41. 41.
    A. DANIELSEN, E. STEINNES, J. Nucl. Med., 11 (1970) 260.PubMedGoogle Scholar
  42. 42.
    M. J. RENAN, C. E. ALBRECHT, D. T. L. JONES, Nucl. Instr. Methods, 181 (1981) 297.Google Scholar
  43. 43.
    H. A. VAN RINSVLT, R. D. LEAR, W. R. ADAMS, Nucl. Instr. Methods, 142 (1977) 171.Google Scholar
  44. 44.
    R. O. ALLEN, E. STEINNES, M. D. BAKER, IAEA-SM-227/57, 1978, p. 447.Google Scholar
  45. 45.
    K. GRIFFITH, E. B. WRIGHT, T. L. DORMANDY, Nature, 241 (1973) 60.Google Scholar
  46. 46.
    A. MARUHASHI, K. KOBAYASHI, K. SHIMA, T. ISHIHARA, T. KUSUMOTO, T. INADA, M. AKISADA, Nucl. Instr. Meth. Phys. Res., B3 (1984) 382.Google Scholar
  47. 47.
    J. H. BLOCK, E. B. ROCHE, T. O. SOIN, C. O. WILSON, Inorganic Medicinal and Pharmaceutical Chemistry, Lea and Febiger, Philadelphia, 1974.Google Scholar
  48. 48.
    C. J. FLICKINGER, J. C. BROWN, H. C. KUTCHAI, J. W. OGILVIE, Medical Cell Biology, Holt Saunders International Editions, 1979.Google Scholar
  49. 49.
    M. SHVAPIL, J. N. RYAN, C. F. ZUKOFSKI, Proc. Soc. Exper. Biol. Med., 140 (1972) 642.Google Scholar
  50. 50.
    M. SHVAPIL, Life Sci., 13 (1973) 1041.PubMedGoogle Scholar
  51. 51.
    M. SHVAPIL, Med. Clin. North. Amer., 60 (1976) 1047.Google Scholar

Copyright information

© Akadémiai Kiadó 1987

Authors and Affiliations

  • V. Papassotiriou
    • 1
  • S. Georgala
    • 1
  • J. Stratigos
    • 1
  • N. Panayotakis
    • 2
  • A. Hadjiantoniou
    • 2
  • A. A. Katsanos
    • 2
  1. 1.“A. SYGROS” HospitalAthensGreece)
  2. 2.Nuclear Research Center “DEMOCRITOS”Aghia ParaskeviGreece)

Personalised recommendations