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Studies of the chemical and biological properties of the bone and acute myocardial imaging agent99mTc-PYP

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Abstract

Correlation between the in vivo distribution and the chemical formulation of99mTc-PYP complex has been studied. We chose mice to evaluate in vivo biodistribution and gel chromatography column scanning technique for radiochemical analysis. The influence of the pH, Sn(II), pyrophosphate concentration and molar ratios of Sn: PYP on the labelling of pyp with99mTc has been investigated in vitro and in vivo. The reaction between99mTc and Sn-PYP was complete within a few minutes. The stability studies were evaluated against dilution. Induced myocardial infarction was evaluated in rats. The clinical evaluation showed excellent definition of sternum and ribs with little blood background activity with normal subjects. Discrete localization of abnormally high activity was shown in the site of recent infarction of the left ventricular myocardium.

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Authors and Affiliations

  1. Radioisotopes Production Department, Nuclear Research Centre, Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital, P. O. Box 765, Baghdad, Iraq)

    Y. F. Shafiq, M. A. A. Al-janabi, M. A. M. Abdel-Azeez, M. H. S. Al-Hissoni & M. M. Jassim

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  1. Y. F. Shafiq
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  2. M. A. A. Al-janabi
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  3. M. A. M. Abdel-Azeez
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  4. M. H. S. Al-Hissoni
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  5. M. M. Jassim
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Shafiq, Y.F., Al-janabi, M.A.A., Abdel-Azeez, M.A.M. et al. Studies of the chemical and biological properties of the bone and acute myocardial imaging agent99mTc-PYP. Journal of Radioanalytical and Nuclear Chemistry, Articles 109, 23–36 (1987). https://doi.org/10.1007/BF02117520

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