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Intratubuläreβ-Glucuronidase-Konzentration bei verschiedenen Diuresezuständen

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Zeitschrift für die gesamte experimentelle Medizin

Zusammenfassung

Stop-flow-Untersuchungen an Hunden ergaben in steigender Mannitdiurese einen Anstieg derβ-Glucuronidase-Konzentration im Harn distaler Tubulusabschnitte, der nach zusätzlicher Calciuminfusion deutlich abfiel. Die Befunde werden im Zusammenhang mit der vonGinetzinsky postulierten Änderung der Hyaluronidase-Aktivität bei mannitinduzierter endogener ADH-Freisetzung diskutiert.

Summary

In eight dogs experiments stop flow analysis was performed in mannitol diuresis. With increasing osmotic diuresis a rise in beta-glucuronidase activity was observed in the urinary fraction distal to the loop of Henle, which decreased markedly following calcium infusion inspite of further increase in diuresis.

The results are discussed in connection with the findings ofGinetzinsky, who observed a rise of urinary hyaluronidase activity during osmotic diuresis and interpreted this as evidence of increased ADH-activity.

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Author notes

  1. Y. Kikuchi, K. Klütsch, A. Heidland & F. Suzuki

    Present address: Medizinischen Universitätsklinik Würzburg, Deutschland

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    1. Y. Kikuchi
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    2. K. Klütsch
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    3. A. Heidland
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    4. F. Suzuki
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    Additional information

    Herrn Professor Dr. E.Wollheim zum 65. Geburtstag.

    Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.

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    Kikuchi, Y., Klütsch, K., Heidland, A. et al. Intratubuläreβ-Glucuronidase-Konzentration bei verschiedenen Diuresezuständen. Z. Gesamte Exp. Med. 139, 604–607 (1965). https://doi.org/10.1007/BF02116876

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    • DOI: https://doi.org/10.1007/BF02116876

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