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Metabolism studies of chlormethiazole by gas chromatography-mass spectrometry

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Summary

The metabolic products of chlormethiazole were extracted from liver and isolated by thin layer chromatography. Chlormethiazole and three other products were obtained. One of these was identified earlier as being 4-methyl-5-β-hydroxy-ethylthiazole and now structures are proposed for the other two. A fourth metabolite, 4-methyl-5-thiazoleacetic acid, was formd in urine. The samples were analyzed by gas chromatography, gas chromatography-mass spectrometry and by high resolution mass spectrometry.

Zusammenfassung

Die Metabolitprodukte von Chlormethiazol wurden aus der Leber extrahiert und mittels Dünnschichtchromatographie isoliert. Es wurden Chlormethiazol und drei andere Produkte nachgewiesen, wobei ein Produkt schon vorher als 4-Methyl-5-β-hydroxy-ethylthiazol identifiziert wurde. Die Strukturformeln für die zwei anderen Produkte wurden vorgeschlagen. Ein vierter Metabolit (4-Methyl-5-thiazolessigsäure) wurde aus Urin erhalten. Die Proben wurden durch Gaschromatographie, Gaschromatographie-Massenspektrometrie und durch hochauflösende Massenspektrometrie analysiert.

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Authors and Affiliations

  1. Government Laboratory for Forensic Chemistry, Stockholm, (Sweden)

    Roger Bonnichsen, Rolf Hjälm, Yvonne Mårde, Marianne Möller & Ragnar Ryhage

  2. Laboratory for Mass Spectrometry, Karolinska Institute, Stockholm, (Sweden)

    Roger Bonnichsen, Rolf Hjälm, Yvonne Mårde, Marianne Möller & Ragnar Ryhage

Authors
  1. Roger Bonnichsen
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  2. Rolf Hjälm
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  3. Yvonne Mårde
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  4. Marianne Möller
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  5. Ragnar Ryhage
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Bonnichsen, R., Hjälm, R., Mårde, Y. et al. Metabolism studies of chlormethiazole by gas chromatography-mass spectrometry. Z Rechtsmed 73, 225–233 (1973). https://doi.org/10.1007/BF02116826

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  • DOI: https://doi.org/10.1007/BF02116826

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