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Drug transport across the blood-brain barrier

III. Mechanisms and methods to improve drug delivery to the central nervous system

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Abstract

This is the third part of a review on the transport of drugs across the blood-brain barrier. In the first two parts, the anatomical and physiological aspects and the various techniques that can be used to study blood-brain transport have been discussed and reviewed. This third part focuses specifically on the mechanisms that are involved in drug transport across the blood-brain barrier. In addition, the opportunities to improve drug transport into the brain will be reviewed. Emphasis is on the transport of peptides.

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Authors and Affiliations

  1. Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, P.O. Box 9503, 2300, RA Leiden, the Netherlands

    J. B. M. M. Van Bree, A. G. De Boer, M. Danhof & D. D. Breimer

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  1. J. B. M. M. Van Bree
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  2. A. G. De Boer
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  3. M. Danhof
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  4. D. D. Breimer
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Van Bree, J.B.M.M., De Boer, A.G., Danhof, M. et al. Drug transport across the blood-brain barrier. Pharm World Sci 15 (Suppl 1), 2–9 (1993). https://doi.org/10.1007/BF02116163

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