Abstract
Plasma testosterone levels in a group of 341 men with sexual dysfunction were compared to those in 199 men with normal sexual function. All subjects were participants in a 2-week intensive conjoint sex therapy program at the Masters & Johnson Institute. Testosterone determinations were made using radioimmunoassay methods after column chromatography; all blood samples were obtained on the second day of therapy between 8:00 and 9:00 a.m. after an overnight fast. Circulating levels of testosterone in men with normal sexual function (mean 635 ng/dl) were not significantly different from testosterone values in sexually dysfunctional men (mean 629 ng/dl). However, men with primary impotence (N = 13) had significantly higher testosterone levels than men with secondary impotence (N = 180), with mean levels of 710 and 574 ng/dl, respectively (p<0.001). The mean testosterone level for men with ejaculatory imcompetence was 660 ng/dl (N = 15), while for men with premature ejaculation the mean was 622 ng/dl (N = 91). Plasma testosterone concentrations were not related to therapy outcome but were correlated negatively with age of patients.
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References
Anonymous (1970). Effects of sexual activity on beard growth in man.Nature 226: 869–870.
Bancroft, J. (1978). The relationship between hormones and sexual behavior in humans. In Hutchison, J. B. (ed.).Biological Determinents of Sexual Behavior, Wiley, Chichester, pp. 493–521.
Beach, F. A. (1947). A review of physiological and psychological studies of sexual behavior in mammals.Physiol. Rev. 27: 240–307.
Beach, F. A. (1977). Hormonal control of sex-related behavior. In Beach, F. (ed.),Human Sexuality in Four Perspectives, The Johns Hopkins University Press, Baltimore, pp. 247–269.
Benkert, O., Horn, K., Pickardt, C. R., and Schmid, D. (1976). Sexual impotence: Studies of the hypothalamic pituitary-thyroid axis and the effects of oral thyrotropin-releasing factor.Arch. Sex. Behav. 4: 275–281.
Carter, J. N., Tyson, J. E., Tolis, G., Van Vliet, S., Faiman, C., and Friesen, H. G. (1978). Prolactin-secreting tumors and hypogonadism in 22 men.New Engl. J. Med. 299: 847–852.
Comhaire, F., and Vermeulen, A. (1975). Plasma testosterone in patients with varicocele and sexual inadequacy.J. Clin. Endocrinol. Metab. 40: 824–829.
Cooper, A. J. (1972). Diagnosis and management of “endocrine impotence.”Br. Med. J. 2: 34–36.
Cooper, A. J., Ismail, A. A. A., Smith, C. G., and Loraine, J. A. (1970). Androgen function in psychogenic and constitutional types of impotence.Br. Med. J. 3: 17–20.
Cooper, A. J., Ismail, A. A. A., Phanjoo, A. L., and Love, D. L. (1972). Antiandrogen (cyproterone acetate) therapy in deviant hypersexuality.Br. J. Psychiat. 120: 159–63.
Davidson, J. M., and Levine, S. (1972). Endocrine regulation of behavior.Ann. Rev. Physiol. 34: 375–408.
Feder, H. H. (1978). Specificity of steroid hormone activation of sexual behavior in rodents. In Hutchinson, J. B. (ed.),Biological Determinants of Sexual Behavior, Wiley, New York, pp. 395–425.
Furayama, S., Mayes, D., and Nugent, C A. (1970). A radioimmunoassay for plasma testosterone.Steroids 16: 415–428.
Goldzieher, J. W., Dozier, T., Smith, K. D., and Steinberger, E. (1976). Improving the diagnostic reliability of rapidly fluctuating plasma hormone levels by optimized multiple sampling techniques.J. Clin. Endocrinol. Metab. 43: 824–830.
Herbert, J. (1974). Some functions of hormones and the hypothalamus in the sexual activity of primates. In Swaab, D. F., and Schade, J. P. (eds.),Progess in Brain Research: Integrative Hypothalamic Activity, Elsevier Scientific Publishing, Amsterdam, pp. 331–346.
Herbert, J. (1978). Neuro-hormonal integration of sexual behavior in female primates. In Hutchinson, J. B. (ed.),Biological Determinants of Sexual Behavior, Wiley, New York, pp. 467–493.
Hudson, B., Burger, H. G., de Kretser, D. M., Coghlan, J. P., and Taft, H. P. (1979). Testosterone plasma levels in normal and pathological conditions. In Rosenberg, R. (ed.),The Human Testis, Plenum, New York, pp. 423–437.
Ismail, A. A. A., Davidson, D. W., Loraine, J. A., Cullen, D. R., Irvine, W. S., Cooper, A. J., and Smith, C. G. (1970). Assessment of gonadal function in impotent men. In Irvine, W. J. (ed.),Reproductive Endocrinology, Livingston, Edinburgh, pp. 138–146.
Kraemer, H. C., Becker, H. B., Brodie, H. K., Doering, C. H., Moos, R., and Hamburg, D. (1976). Orgasmic frequency and plasma testosterone levels in normal human males.Arch. Sex. Behav. 5: 125–132.
Kreuz, L. E., Rose, R. M., and Jennings, J. R. (1972). Suppression of plasma testosterone levels and psychological stress: A longitudinal study of young men in officers candidate school.Arch. Gen Psychiat. 26: 479–482.
Laschet, U. (1969). Die Anwendarbeit von Antiandrogenen in der Humanmedizin.Saarlaend. Aerztebl. 22: 370–71.
Lawrence, D. M., and Swyer, G. I. M. (1974). Plasma testosterone and testosterone binding affinities in men with impotence, oligospermia, azoospermia and hypogonadism.Br. Med. J. 1: 349–351.
Legros, J. J., Palem, M., Servais, J., Margoulies, M., and Franchmont, P. (1974a). Basal pituitary-gonadal function in impotency evaluated by blood testosterone and LH assays. In Lissak, K. (ed.),Hormones and Brain Function, Plenum, New York.
Legros, J. J., Servais, J., and Mormont, C. (1974b). A preliminary study of psychoneuroendocrine relationships in psychogenic impotence.Psychoneuroendocrinology 1: 203–205.
Luttge, W. G. (1971). The role of gonadal hormones on the sexual behavior of the rhesus monkey and human: A literature survey.Arch. Sex Behav. 1: 61–88.
Masters, W. H., and Johnson, V. E. (1970).Human Sexual Inadequacy, Little,Brown, Boston.
McGregor, A. M., Scanlon, M. F., Hall, K., Cook, D. B., and Hall, R. (1979). Reduction in size of a pituitary tumor by bromocryptine therapy.New Engl. J. Med. 300: 291–293.
Michael, R. P. (1971). Neuroendocrine factors regulating primate behavior. In Martini, L., and Ganong, W. F. (eds.),Frontiers of Neuroendocrinology, Oxford University Press, London, pp. 359–398.
Money, J. (1961a). Sex hormones and other variables in human eroticism. In Young, W. C. (ed.),Sexual and Internal Secretions, 3rd ed., Williams and Wilkins, Baltimore, pp. 1381–1401.
Money, J. (1961b). Components of eroticism in man. I. The hormones in relation to sexual morphology and sexual desire.J. Nerv. Ment. Dis. 132: 239–248.
Money, J. (1970). Use of an androgen depleting hormone in the treatment of male sex offenders.J. Sex Res. 6: 165–172.
Money, J., Wiedeking, C., Walker, P., Migeon, C., Meyer, W., and Borgaonkar, D. (1975). 47, XYY and 46, XY males with antisocial and/or sex offending behavior: Antiandrogen therapy plus counseling.Psychoneuroendocrinology 1: 165–170.
Morse, H. C., Leach, D. R., Rowley, M. J., and Heller, C. G. (1973). Effect of cyproterone acetate on sperm concentration, seminal fluid volume, testicular cytology and levels of plasma and urinary ICSH, FSH and testosterone in normal men.J. Reprod. Fertil. 32: 365–378.
Murray, M. A. F., and Corker, C. S. (1973). Levels of testosterone and luteinzing hormone in plasma samples taken at 10-minute intervals in normal men.J. Endocrinol. 56: 157–159.
Raboch, J., Mellan, J., and Starka, L. (1975). Plasma testosterone in male patients with sexual dysfunction.Arch. Sex. Behav. 4: 309–315.
Racey, P. A., Ansari, M. A., Rowe, P. H., and Glover, T. (1973). Testosterone in impotent men.J. Endocrinol. 59: xxiii.
Rose, R. M. (1972). The psychological effects of androgens and estrogens—A review. In Shader, R. I. (ed.),Psychiatric Complications of Medical Drugs, Raven Press, New York, pp. 251–293.
Rosenfield, R. L. (1975). Studies of the relation of plasma androgen levels to androgen action in women.J. Steroid Biochem. 6: 695–702.
Rowe, P. H., Lincoln, G. A., Racey, P. A., Lehane, J., Stephenson, M. J., Shenton, J. C., and Glover, T. D. (1974). Temporal variations of testosterone levels in the peripheral blood plasma of men.J. Endocrinol. 61: 63–72.
Schiavi, R. C., and White, D. (1976). Androgens and male sexual function: A review of human studies.J. Sex Marital Ther. 2: 214–230.
Stearns, E. I., Winter, J. S. D., and Faiman, C. (1973). Effects of coitus on gonadotropin, prolactin, and sex steroid levels in man.J. Clin. Endocrinol. Metab. 37: 687–690.
Urban, M. D., Lee, P. A., Kowarski, A. Plotnick, L., and Migeon, C. (1979). Comparison of estimates of gonadotropin levels by isolated blood samples, integrated blood concentrations, and timed urinary fractions.J. Clin. Endocrinol. Metab. 48: 732–734.
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Schwartz, M.F., Kolodny, R.C. & Masters, W.H. Plasma testosterone levels of sexually functional and dysfunctional men. Arch Sex Behav 9, 355–366 (1980). https://doi.org/10.1007/BF02115938
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DOI: https://doi.org/10.1007/BF02115938