Abstract
Desmopressin (DDAVP) is frequently used in the treatment of primary isolated enuresis nocturna if other approaches have failed. We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis
Similar content being viewed by others
Abbreviations
- ADH :
-
antidiuretic hormone
- DDAVP :
-
I-deaminocystein-8-d-arginine-vasopressin
References
Aladjem M, Wohl R, Biochis H, Orda S, Lotan D, Freeman S (1982) Desmopressin in nocturnal enuresis. Arch Dis Child 57:137–140
Alon US (1995) Nocturnal enuresis. Pediatr Nephrol 9:94–103
Bamford MFM, Cruickshank G (1989) Dangers of intranasal desmopressin for nocturnal enuresis. J R Coll Gen Pract 345–346
Beetz R (1993) Funktionelle Aspekte der Enuresis im Kindesalter — Bedeutung für Diagnostik und Therapie. Aktuel Urol 24:241–250
Fjellestad-Paulsen A, Wille S, Harris AS (1987) Comparison of intranasal and oral desmopressin for nocturnal enuresis. Arch Dis Child 62:674–677
Janknegt RA, Smans AJ (1990) Treatment with desmopressin in severe nocturnal enuresis in childhood. Br J Urol 66:535–537
Klauber GT (1989) Clinical efficacy and safety of desmopressin in the treatment of nocturnal enuresis. J Pediatr 114:691–696
Knudsen UB, Rittig S, Norgaard JP, Lundemose JB, Pedersen EB, Djurhuus JC (1991) Long-term treatment of nocturnal enuresis with desmopressin, a follow up study. Urol Res 19:237–240
Kohler M, Harris A (1988) Pharmacokinetics and haematological effects of desmopressin. Eur J Clin Pharmacol 35: 281–285
Marild S, Jodal U, Jonasson G, Mangelus L, Oden A, Persson N-G (1992) Reterence values for renal concentrating capacity in children by the demopressin test. Pediatr Nephrol 6:254–257
Miller K, Klauber GT (1990) Desmopressin acetate in children with severe primary nocturnal enuresis. Clin Ther 12:357–366
Miller K, Atkin B, Moody ML (1992) Drug therapy for nocturnal enuresis. Current treatment recommendations. Drugs 44:47–56
Moffatt MEK, Harlos S, Kirshen AJ, Burd L (1993) Desmopressin acetate and nocturnal enuresis: how much do we know? Pediatrics 92:420–425
Muglia L, Goddman E, Peters C, Majzoub J (1992) Symptomatic hyponatriemia secondary to dDaVP treatment for primary enuresis. Pediatr Res 31: 81A
Rew DA, Rundle JSH (1989) Assessment of the safety of regular DDAVP therapy in primary nocturnal enuresis. Br J Urol 63:352–353
Rittig S, Knudsen UB, Sorensen S, Djurhuus, JC, Norgaard JP (1989) Long-term doubleblind cross-over study of desmopressin intranasal spray in the management of nocturnal enuresis. In: Meadow SR (ed) Desmopressin in nocturnal enuresis. Proceedings of an International Symposium on Desmopressin in Nocturnal Enuresis, London 1988, pp 43–54
Simmonds EJ, Mahhony MJ, Littlewood JM (1988) Convulsion and coma after intranasal desmopressin in cystic fibrosis. BMJ 297:1614
Sukhai RN (1993) Enuresis nocturna: long term use and safety aspects of minirin (desmopressin) spray. Regul Pept 45:309–310
Terho P (1991) Desmopressin in nocturnal enuresis. J Urol 145:818–820
Vavra K, Machova L, Holocek V, Cort JH, Zaoral M, Sorm F (1968) Effect of a synthetic analogue of vasopressin in animals, and in patients with diabetes insipidus. Lancet I:948–952
Wille S (1986) Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child 61:30–33
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schwab, M., Wenzel, D. & Ruder, H. Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturna. Eur J Pediatr 155, 46–48 (1996). https://doi.org/10.1007/BF02115626
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02115626