Abstract
Propionylcarnitine (PC) excretion has been measured during a clinical trial of metronidazole therapy in two patients with propionic acidaemia and two patients with methylmalonic aciduria. All patients were in good metabolic control and were receivingl-carnitine. While total propionate excretion was reduced by up to 40% in all four patients during metronidazole therapy, the excretion of propionylcarnitine remained largely unchanged. PC comprised up to 80% of total propionate excretion in patients with propionic acidaemia.
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Abbreviations
- 1 H NMR :
-
proton nuclear magnetic resonance
- PC :
-
propionylcarnitine
- TSP :
-
3-(trimethylsilyl)propionic-2,2,3,3-d4 acid
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Burns, S.P., Iles, R.A., Saudubray, J.M. et al. Propionylcarnitine excretion is not affected by metronidazole administration to patients with disorders of propionate metabolism. Eur J Pediatr 155, 31–35 (1996). https://doi.org/10.1007/BF02115623
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DOI: https://doi.org/10.1007/BF02115623