Summary
The findings during a study of human red cell phosphogluconate dehydrogenase polymorphism in the population of West-Berlin are reported. Application of a discontinuous citrate-phosphate buffer system makes possible the combined detection of PGD- and AK-phenotypes in a single electrophoretical run. The results in the Berlin-survey supports the hypothesis of two allele genes with codominant autosomal transmission. The significance in paternity cases is discussed.
Zusammenfassung
Es wird über die Ergebnisse bei der Bestimmung der PGD-Phänotypen an 544 nichtkorrelierten Personen, 203 Mutter-Kind-Paaren und in 151 Vaterschaftssachen berichtet.
Eine Abwandlung der Methode ermöglicht die kombinierte Bestimmung mit den AK-Typen in einem Arbeitsgang.
Die Untersuchungsergebnisse stehen in Einklang mit der Annahme eines kodominanten Erbgangs zweier alleler Gene PGDA und PGDB an autosomalem Ort.
Die Bedeutung des PGD-Systems für die Vaterschaftsbegutachtung wird diskutiert.
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Smerling, M. Phosphogluconat-Dehydrogenase (PGD). Stichprobe aus der Berliner Bevölkerung. Z Rechtsmed 68, 20–26 (1971). https://doi.org/10.1007/BF02115544
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DOI: https://doi.org/10.1007/BF02115544