The human genes for the α and γ subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1823
- 207 Downloads
The receptor with high affinity for immunoglobulin E (FcERI) is a key molecule in triggering the allergic reaction. It isα tetrameric complex of oneα subunit, oneβ subunit, and two disulfide-linkedγ subunits. This receptor is present exclusively on mast cells and basophils. Molecules identical to theγ subunit of FcεRI also formα cell surface complex with other Fc receptors such as mouse FcγRIIa in macrophages and most probably with human FcγRIII (CD16) in natural killer (NK) cells. Here we show by in situ hybridization that the human genes for theα (FCER1A) and γ subunits (FCER1 G) of FcERI and the gene for FcγRIII (FCGR3, CD16) are located on human chromosome band 1823.
KeywordsCell Surface Natural Killer Mast Cell Cell Receptor Allergic Reaction
Unable to display preview. Download preview PDF.
- Hibbs, M. L., Selvaraj, P., Carpen, O., Springer, T. A., Küster, H., Jouvin, M.-H. E., and Kinet, J. P.: Mechanisms for regulating expression of membrane isoforms of FcγRIII (CD16).Science, in press, 1990Google Scholar
- Weissman, A. M., Hou, D., Orloff, D. G., Modi, W. S., Seuanez, H., O'Brien, S. J., and Klausner, R. D.: Molecular cloning and chromosomal localization of the human T-cell receptorζ chain: distinction from the CD3 complex.Proc Natl Acad Sci USA 85: 9709–9713, 1989Google Scholar