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Archives of gynecology

, Volume 233, Issue 3, pp 225–228 | Cite as

Experience with an industrially manufactured gel PGE2 for cervical priming

  • J. Floberg
  • J. Allen
  • P. Belfrage
  • M. Bygdeman
  • U. Ulmsten
Original Papers

Summary

An industrially manufactured ready-to-use PGE2 gel for cervical ripening was clinically evaluated. The study included 42 primiparous and eight multiparous women with an unfavourable cervix (Bishop score ⩽ 5) admitted to hospital for induction of labour on medical grounds. PGE2, 0.5 mg, in 2 ml triacetin gel was instilled into the cervical canal. In nine patients (18%) the gel induced labour and subsequent delivery. In the remaining women the mean Bishop score increased from 3.0 to 7.7 during a 24-h period and labour was induced by either i.v. oxytocin or PGF. None of the 50 patients experienced gastrointestinal side effects during pretreatment with PGE2. In 50% of the patients slight uterine contractility was noticed. All patients went into labour. The incidence of Cesarean section was 10%. Except for two patients treated because of intrauterine fetal death there was no perinatal mortality. The 5-min Apgar score was 8 or more in all newborn but 1. The main advantage of the new gel is that it is ready to use without any mixing procedure. Moreover, the stability of PGE2 is sufficient to allow routine clinical use.

Key words

Prostaglandin E2 Gel Local application Ripening of the cervix 

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References

  1. 1.
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    Calder AA (1979) Prostaglandins for pre-induction cervical ripening. In: Karim SMM (ed) Practical applications of prostaglandins and their synthesis inhibitors. Lancaster MTP Press, pp 301–318Google Scholar
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    Ulmsten U, Wingerup L (1980) Clinical experience with a new gel for intracervical application of prostaglandin E2 before therapeutic abortion or induction of term labour. Prostaglandins 20: 533–546CrossRefPubMedGoogle Scholar
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    Ulmsten U, Wingerup L, Belfrage P, et al. (1981) Intracervical application of prostaglandin gel for induction of term labour. Obstet Gynecol 59: 336–339Google Scholar
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    Wingerup L, Andersson K-E, Ulmsten U (1978) Ripening of the uterine cervix and induction of labour at term with prostaglandin E2 in viscous gel. Acta Obstet Gynecol Scand 57: 403–406PubMedGoogle Scholar

Copyright information

© J. F. Bergmann Verlag 1983

Authors and Affiliations

  • J. Floberg
    • 1
  • J. Allen
    • 2
  • P. Belfrage
    • 1
  • M. Bygdeman
    • 1
  • U. Ulmsten
    • 2
  1. 1.Dept. of Obstetrics and GynecologyKarolinska HospitalStockholmSweden
  2. 2.Dept. of Obstetrics and GynecologyUniversity of ÅrhusÅrhusDenmark

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