Infection

, Volume 25, Issue 2, pp 112–116 | Cite as

Multifocal osteoarthritis due toCandida albicans in a neonate: Serum level monitoring of liposomal amphotericin B and literature review

  • J. Evdoridou
  • G. Kremenopoulos
  • E. Roilides
  • E. Bibashi
Brief Report

Summary

A 32-week neonate weighing 2,300 g at birth with fungemia due toCandida albicans subsequently developed multifocal osteoarthritis of the lower extremities due to the same organism during therapy with amphotericin B (0.5 mg/kg/day) and flucytosine (100 mg/kg/day) to which the isolates were susceptible. Liposomal amphotericin B (3.5 mg/kg/day) was substituted for conventional amphotericin B and complete clinical and radiologic recovery as well as sterilization of affected joints were achieved with a 38-day-course (144.5 mg/kg total). Adequate drug concentrations in serum and synovial fluid were attained with liposomal amphotericin B. Nine neonates (≤28 days of age) with bone and/or joint infections due toCandida spp. had previously been reported in the English-language literature. To our knowledge, the present case is the first reported cure with liposomal amphotericin B. Previous cases are reviewed and the potential role of liposomal amphotericin B in this serious neonatal infection is discussed.

Keywords

Osteoarthritis Drug Concentration Lower Extremity Amphotericin Synovial Fluid 

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Copyright information

© MMV Medizin Verlag GmbH München 1997

Authors and Affiliations

  • J. Evdoridou
    • 1
  • G. Kremenopoulos
    • 1
  • E. Roilides
    • 3
  • E. Bibashi
    • 2
  1. 1.Dept. of NeonatologyUniversity of Thessaloniki, Hippokration HospitalThessalonikiGreece
  2. 2.Dept. of MicrobiologyUniversity of Thessaloniki, Hippokration HospitalThessalonikiGreece
  3. 3.3rd Dept. of PediatricsUniversity of Thessaloniki, Hippokration HospitalThessalonikiGreece

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