Summary
On the basis of the results of a collaborative study the Expert Committee on Biological Standardisation of the World Health Organisation has issued an international standard (IS) serum for parvovirus B19 IgG antibody (NIBSC 93/724). In this study this IS was used to calibrate an in-house standard serum for reporting the results of parvovirus B19 IgG testing in IU/ml. The IgG titre distribution in 939 pregnant women was determined. These samples were sent to the laboratory for determining the immune status to parvovirus B19 following contact with parvovirus B19 infected individuals or for detecting acute infection in patients with symptoms suggestive of parvovirus B19 infection.
References
Cohen, B. Parvovirus B19: an expanding spectrum of disease. Br. Med. J. 311 (1995) 1549–1552.
Public Health Laboratory Service Working Party of Fifth Disease Prospective study of human parvovirus (B19) infection in pregnancy. Br. Med. J. 300 (1990) 1166–1170.
Schwarz, T. F., Nerlich, A., Roggendorf, H., Hottenträger, B., Jäger, G., Schramm, T., Gloning, K. P., Roggendorf, M. Parvovirus B19 infection in pregnancy. Int. J. Exp. Clin. Chemother. 3 (1990) 219–223.
Ferguson, M., Walker, D., Cohen, B.: Report of a collaborative study to assess the suitability of the proposed international standard for parvovirus B19 serum IgG. Biologicals, in press.
Bansal, G. P., Hatfield, J. A., Dunn, F. E., Kramer, A. A., Brady, F., Riggin, C. H., Collett, M. S., Yoshimoto, K., Kajigaya, S., Young, N. S. Candidate recombinant vaccine for human B19 parvovirus. J. Infect. Dis. 167 (1993) 1034–1044.
Enders, G.: Infections of the fetus and neonate other than rubella. In:Collier, L. (ed.): Topley & Wilson's Microbiology and Microbial Infections, 9th ed. Edward Arnold, London, in press.
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Searle, K., Guilliard, C. & Enders, G. Parvovirus B19 diagnosis in pregnant women — quantification of IgG antibody levels (IU/ml) with reference to the international parvovirus B19 standard serum. Infection 25, 32–34 (1997). https://doi.org/10.1007/BF02113504
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DOI: https://doi.org/10.1007/BF02113504