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«Affinity Labelling» des cholinergischen Rezeptors der motorischen Endplatte mit Diazo-Acetylcholin

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Summary

Diazoacetylcholinebromide was used for affinity labelling of the cholinergic receptors of endplates in the mouse diaphragm. Under irradiation by light (Hg-high-pressure-lamp), irreversible depolarizing block of neuromuscular transmission developed. Acetylcholinesterase was influenced only by much higher concentrations, which demonstrates different localizations of the active enzyme center and the cholinergic receptor.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Zürich, Gloriastrasse 32, CH-8006, Zürich, Schweiz

    P. G. Waser, A. Hofmann & W. Hopff

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  1. P. G. Waser
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  2. A. Hofmann
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  3. W. Hopff
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Waser, P.G., Hofmann, A. & Hopff, W. «Affinity Labelling» des cholinergischen Rezeptors der motorischen Endplatte mit Diazo-Acetylcholin. Experientia 26, 1342–1343 (1970). https://doi.org/10.1007/BF02113018

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  • DOI: https://doi.org/10.1007/BF02113018

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