«Affinity Labelling» des cholinergischen Rezeptors der motorischen Endplatte mit Diazo-Acetylcholin
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Diazoacetylcholinebromide was used for affinity labelling of the cholinergic receptors of endplates in the mouse diaphragm. Under irradiation by light (Hg-high-pressure-lamp), irreversible depolarizing block of neuromuscular transmission developed. Acetylcholinesterase was influenced only by much higher concentrations, which demonstrates different localizations of the active enzyme center and the cholinergic receptor.