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Experientia

, Volume 26, Issue 12, pp 1342–1343 | Cite as

«Affinity Labelling» des cholinergischen Rezeptors der motorischen Endplatte mit Diazo-Acetylcholin

  • P. G. Waser
  • A. Hofmann
  • W. Hopff
Specialia Pharmacologica

Summary

Diazoacetylcholinebromide was used for affinity labelling of the cholinergic receptors of endplates in the mouse diaphragm. Under irradiation by light (Hg-high-pressure-lamp), irreversible depolarizing block of neuromuscular transmission developed. Acetylcholinesterase was influenced only by much higher concentrations, which demonstrates different localizations of the active enzyme center and the cholinergic receptor.

Copyright information

© Birkhäuser-Verlag 1970

Authors and Affiliations

  • P. G. Waser
    • 1
  • A. Hofmann
    • 1
  • W. Hopff
    • 1
  1. 1.Pharmakologisches Institut der Universität ZürichZürichSchweiz

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