Summary
In prolactinoma surgery, especially in macro-adenomas, it is not always possible to remove the tumour totally. Cell remnants may cause a regrowth and continue hypersecretion. In order to find out whether tumour remnants could be destroyed by local application of bromocriptine, a research model has been designed. First, prolactin secreting pituitary tumours, removed during surgery, were implanted bilaterally into the brain tissue of rats. In eight rats, the viability of tumour transplants was proven histopathologically and their prolactin secretion was shown immunocytochemically. In a second step, on eight rats, sterile bromocriptine solution was applied topically to the tumour transplants on one side. The other side served as control.
Histopathological examination of these treated tissues revealed fibrosis. Immunocytochemical analysis showed no secretory activity. Ultrastructural investigations also revealed evidence of degeneration of the treated cells.
The natural course of the transplanted tumour tissues of the other side, as a control group, was also observed during the same 55-day period.
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References
Bang S, Gautvik KM (1977) Inhibition of prolactin secretion and synthesis by dopamine, noradrenaline and pilocarpine in cultured rat pituitary tumour cells. Acta Pharmacol Toxicol 41: 317–327
Bassetti M, Spada A, Pezzo G,et al (1984) Bromocriptine treatment reduces the cell size in human macroprolactinomas, A morphometric study. J Endocrinol Metab 58: 268–273
Del Pozo E, BrunDel Re R, Valga L, Friesen H (1972) The inhibition of prolactin secretion in man by CB-154 (2-Br-alphaergocryptine). J Clin Endocrinol Metab 35: 768
Erbengi T, Erbengi A, Canbolat A,et al (1988) Electron microscopical investigation of the endocrine-active pituitary adenomas. Inst Phys Conf Ser 93: 263–264
Gen M, Uozumi T, Ohta M,et al (1984) Necrotic changes in prolactinomas after long term administration of bromocriptine. J Clin Endocrinol Metab 59: 463–470
Lamberts SW, MacLeod RM (1979) The inability of bromocriptine to inhibit prolactin secretion by transplantable rat pituitary tumours: observations on the mechanisms and dynamics of the autofeedback regulation of prolactine secretion. Endocrinology 104: 65–70
Landolt AM, Minder H, Osterwalder V,et al (1983) Bromocriptine reduces the size of cells in prolactin-secreting pituitary adenomas. Experientia 39: 625–626
Landolt AM, Wilson CB (1982) Tumors of the sella and parasellar area in adults. In: Youmans JL (ed) Neurological surgery. Saunders, Philadelphia, pp 3107–3162
Lis M, Cantin M, Marchisio AM,et al (1984) Estrone induced prolactin secreting and dopamine-sensitive rat pituitary tumor. Eur J Cancer Clin Oncol 20: 829–839
Miyawaki H, Ishii S (1960) The heterologous intracerebral transplantation of human brain tumours. Arch Pathol 70: 508–519
Mori H, Mori S, Saitoh Y,et al (1985) Effects of bromocriptine on prolactin-secreting pituitary adenomas. Cancer 56: 230–238
Quadri SK, Lu KH, Meites J (1972) Ergot induced inhibition of pituitary tumor growth in rats. Science 176: 417–418
Rengachary SS, Tomita T, Jefferies BF,et al (1982) Structural changes in human pituitary tumor after bromocriptine therapy. Neurosurgery 10: 242–251
Saitoh Y, Mori S, Arita N,et al (1986) Cytosuppressive effect of bromocriptine on human prolactinomas: stereological analysis of ultrastructural alterations with special reference to secretory granules. Cancer Res 46: 1507–1512
Tindall GT, Kovacs K, Horvarth E, Thorner MO (1982) Human prolactin-producing adenomas and bromocriptine: a histological immunocytochemical, ultrastructural and morphometric study. J Clin Endocrinol Metab 55: 1178–1183
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Açikgöz, B., Özgen, T., Özcan, O.E. et al. Topical effect of bromocriptine on rat-transplanted human prolactinomas. Acta neurochir 120, 175–179 (1993). https://doi.org/10.1007/BF02112038
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DOI: https://doi.org/10.1007/BF02112038