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D-arabinitol versus mannan antigen and candidal protein antigen as a serum marker forCandida pyelonephritis

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Abstract

To evaluate serum markers for the diagnosis ofCandida pyelonephritis, levels of D-arabinitol, candidal mannan antigen and candidal protein antigen were measured using an enzymatic fluorometric assay, an enzyme immunoassay and a latex agglutination assay, respectively. The study group comprised 36 patients with candiduria (11 disseminated candidiasis, 9Candida pyelonephritis and 16 colonization) and 27 without candiduria. The D-arabinitol/creatinine ratio was the only marker that differentiated betweenCandida pyelonephritis and colonization (p<0.01). Using the cut-off values (1.4 µmol/mg of D-arabinitol/creatinine ratio, 0.28 of mannan/creatinine ratio (×104) and 1:4 of protein antigen titer) D-arabinitol/creatinine ratio showed the highest sensitivity inCandida pyelonephritis (77.8 %) as compared to mannan/creatinine ratio (55.6 %) and protein antigen titer (11.1 %) although there were no differences in specificity, positive predictive value or negative predictive value. These results suggest that D-arabinitol/creatinine ratio is the most useful marker ofCandida pyelonephritis.

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Authors and Affiliations

  1. Department of Urology School of Medicine, Kanazawa University, Takaramachi 13-1, 920, Kanazawa, Japan

    S. Tokunaga, M. Ohkawa, M. Takashima & C. Seto

  2. Department of Bacteriology, School of Medicine, Kanazawa University, Takaramachi 13-1, 920, Kanazawa, Japan

    S. Nakamura

Authors
  1. S. Tokunaga
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  2. M. Ohkawa
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  3. M. Takashima
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  4. C. Seto
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  5. S. Nakamura
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Tokunaga, S., Ohkawa, M., Takashima, M. et al. D-arabinitol versus mannan antigen and candidal protein antigen as a serum marker forCandida pyelonephritis. Eur. J. Clin. Microbiol. Infect. Dis. 14, 118–121 (1995). https://doi.org/10.1007/BF02111869

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  • DOI: https://doi.org/10.1007/BF02111869

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