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Aminoglycosides: The complex problem of antibiotic mechanisms and clinical applications

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References

  1. Dalhoff A: Pleiotropic actions of aminoglycosides. In: Doring G, Holder IA, Botzenhart K (ed): Antibiotics and chemotherapy. Basic research and clinical aspects ofPseudomonas aeruginosa. Basel, Switzerland, 1987, p. 182–204.

  2. Davis DB: Mechanism of bactericidal action of aminoglycosides. Microbiological Reviews 1987, 51: 341–350.

    PubMed  Google Scholar 

  3. Bryan LE, Kwan S: Roles of ribosomal binding membrane potential and electron transport in bacterial uptake of streptomycin and gentamicin. Antimicrobial Agents and Chemotherapy 1983, 26: 835–845.

    Google Scholar 

  4. Taber HW, Meuller JP, Miller PF, Arnow AS: Bacterial uptake of aminoglycoside antibiotics. Microbiological Reviews 1987, 51: 439–457.

    PubMed  Google Scholar 

  5. Schlessinger D: Failure of aminoglycosides to kill anaerobic, low-pH and resistant cultures. Clinical Microbiology Reviews 1988, 1: 54–59.

    PubMed  Google Scholar 

  6. Bellido F, Hancock REW: Susceptibility and resistance ofPseudomonas aeruginosa to antimicrobial agents. In: Canya M, Bendinella M, Freidman H (ed):Pseudomonas aeruginosa as an opportunistic pathogen, Plenum Press, New York, 1993, p. 321–348.

    Google Scholar 

  7. Vaara M: Agents that increase the permeability of the outer membrane. Microbiological Reviews 1992, 56: 395–411.

    PubMed  Google Scholar 

  8. Hancock REW: Alterations in outer membrane permeability. Annual Reviews of Microbiology 1984, 38: 237–264.

    Google Scholar 

  9. Hancock REW, Bell A: Antibiotic uptake into gramnegative bacteria. European Journal of Clinical Microbiology & Infectious Diseases 1988: 7: 713–720.

    Google Scholar 

  10. Peterson A, Hancock REW, McGroarty EJ: Binding of polycationic antibiotics and polyamines to lipopolysaccharides ofPseudomonas aeruginosa. Journal of Bacteriology 1985, 164: 1256–1261.

    PubMed  Google Scholar 

  11. Walker SG, Beveridge TJ: Amikacin disrupts the cell envelope ofPseudomonas aeruginosa. Canadian Journal of Microbiology 1988, 34: 12–18.

    PubMed  Google Scholar 

  12. Kadurugamua JL, Clarke AJ, Beveridge TJ: Surface action of gentamicin onPseudomonas aeruginosa. Journal of Bacteriology 1993, 175: 5798–5805.

    PubMed  Google Scholar 

  13. Raulston JE, Montie TC: Early cell envelope alterations by tobramycin associated with its lethal action onPseudomonas aeruginosa. Journal of General Microbiology 1989, 135: 3023–3034.

    PubMed  Google Scholar 

  14. Davies J: Inactivation of antibiotics and the dissemination of resistance genes. Science 1994, 264: 375–382.

    PubMed  Google Scholar 

  15. Nikaido H: Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 1994, 264: 382–388.

    PubMed  Google Scholar 

  16. Gilleland LB, Gilleland HE: Adaptive resistance to aminoglycoside antibiotics inPseudomonas aeruginosa: role of phospholipid alterations in resistance. Journal of Medical Microbiology 1988, 29: 41–50.

    Google Scholar 

  17. Raz R, Adawi M, Romano S: Intravenous gentamicin, once versus thrice daily in adults. European Journal of Clinical Microbiology and Infectious Diseases 1995, 14: 88–91.

    Google Scholar 

  18. Gilbert DN: Once-daily aminoglycoside therapy. Antimicrobial Agents and Chemotherapy 1991, 35: 399–405.

    PubMed  Google Scholar 

  19. Prins JM, Buller HR, Kuijper EJ, Tange RA, Speelman P: Once versus thrice daily gentamicin in patients with serious infections. Lancet 1993, 341: 335–339.

    PubMed  Google Scholar 

  20. Nordstrom L, Ring-berg H, Cronberg S, Tjernstrom O, Walder M: Does administration of an aminogly-coside in a single daily dose affect its efficacy and toxicity? Journal of Antimicrobial Chemotherapy 1990, 29: 159–173.

    Google Scholar 

  21. Debroe ME, Verbist L, Verpooten GA: Influence of dosage schedule on renal cortical accumulation of amikacin and tobramycin in man. Journal of Antimicrobial Chemotherapy 1991, 27, Supplement C: 41–47.

    Google Scholar 

  22. Rajkumar SV, Koo JM: Letter to the editor. Lancet 1993, 341: 895.

    Google Scholar 

  23. Craig WA, Vogelman B: The postantibiotic effect. Annals of Internal Medicine 1987, 106: 900–902.

    PubMed  Google Scholar 

  24. Labovitz E, Levinson ME, Kaye S: Single dose daily gentamicin therapy in urinary tract infection. Antimicrobial Agents and Chemotherapy 1974, 6: 465–470.

    PubMed  Google Scholar 

  25. Meunier F, Auwera PV, Aoon M, Ibrahim S, Tulkens PM: Empirical antimicrobial therapy with a single daily dose of ceftriaxone plus amikacin in febrile granulocytopenic patients: a pilot study. Journal of Antimicrobial Chemotherapy 1991, 27, Supplement C: 129–139.

    PubMed  Google Scholar 

  26. Bates RD, Nahata MC: Once daily administration of aminoglycosides. Annals of Pharmacotherapy 1994, 28: 757–765.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, M409 Walters Life Sciences Building, University of Tennessee, 37996, Knoxville, Tennessee, USA

    T. Montie

  2. Division of Infectious Diseases, Department of Pediatrics, University of Tennessee Medical Center, U-113, 37920, Knoxville, Tennessee, USA

    P. Patamasucon

Authors
  1. T. Montie
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  2. P. Patamasucon
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Montie, T., Patamasucon, P. Aminoglycosides: The complex problem of antibiotic mechanisms and clinical applications. Eur. J. Clin. Microbiol. Infect. Dis. 14, 85–87 (1995). https://doi.org/10.1007/BF02111863

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