Treatment of cerebrospinal fluid shunt infections with teicoplanin
- 61 Downloads
Intraventricular teicoplanin 10–15 mg was administered daily to three patients with cerebrospinal fluid (CSF) shunt infections due toStaphylococcus epidermidis andEnterococcus faecalis. Teicoplanin concentrations in CSF 24 h after intrathecal injection of the drug exceeded four- to eight-fold the MICs for the infecting microorganisms. CSF cultures rapidly became negative and shunt devices were withdrawn and replaced in the same operative procedure. Intraventricular teicoplanin was well tolerated. No relapses occurred. Teicoplanin may be an alternative to vancomycin for the antimicrobial therapy of CSF shunt infections.
KeywordsInternal Medicine Operative Procedure Cerebrospinal Fluid Vancomycin Antimicrobial Therapy
Unable to display preview. Download preview PDF.
- 6.Lalla F, Santoro D, Rinaldi E, Suter F, Cruciani M, Gaglianone MH, Rizzardini G, Pellegata G Teicoplanin in the treatment of infections by staphylococci,Clostridium difficile and other gram-positive bacteria. Journal of Antimicrobial Chemotherapy 1989, 23: 131–142.Google Scholar
- 9.Maserati R, Cruciani M, Azzini M, Carnevale C, Suter F, Concia E Teicoplanin in the therapy of staphylococcal neuroshunt infections. International Journal of Clinical and Pharmacologic Research 1987, 7: 207–213.Google Scholar