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Activity of the fourth generation cephalosporin FK-037 against methicillin-resistantStaphylococcus aureus under conditions maximizing PBP2′ production

  • New Antimicrobial Agent
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Abstract

To investigate the in vitro activity of the fourth generation cephalosporin FK-037, MICs were determined for 80 strains of methicillin-resistantStaphylococcus aureus from 11 countries. Methicillin and cefamandole served as comparators. The method ensured good expression of PBP2′ by use of a large inoculum, salt supplement and incubation for 48 hours at 30°C. FK-037 was twice as active as cefamandole against both strains with high-level and strains with low-level methicillin resistance (geometric mean MICs 23.4 and 10.8 mg/l, respectively).

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  1. Department of Medical Microbiology, Royal Free Hospital School of Medicine, Pond Street, NW3 2QG, London, UK

    J. M. T. Hamilton-Miller

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  1. J. M. T. Hamilton-Miller
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Hamilton-Miller, J.M.T. Activity of the fourth generation cephalosporin FK-037 against methicillin-resistantStaphylococcus aureus under conditions maximizing PBP2′ production. Eur. J. Clin. Microbiol. Infect. Dis. 13, 1053–1055 (1994). https://doi.org/10.1007/BF02111826

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