Non-canonical mechanisms of antibiotic resistance

  • J. L. Martínez
  • J. Blázquez
  • F. Baquero


Although the current in vitro methods used for detection and analysis of the phenotypes of antibiotic resistance in the laboratory are well established, other resistance mechanisms of resistance exist which may escape detection using the standard approach. The present article reviews some of these mechanisms which are grouped under the term ‘non-canonical mechanisms’ of antibiotic resistance. Such mechanisms include gene dosage, heterologous induction or selection, populational resistance and synergism between mechanisms of low resistance. The role of these mechanisms in the failure of therapy is discussed.


Internal Medicine Antibiotic Resistance Present Article Resistance Mechanism Standard Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • J. L. Martínez
    • 1
  • J. Blázquez
    • 2
  • F. Baquero
    • 2
  1. 1.Centro Nacional de BiotecnologíaUniversidad Autónoma de Madrid, CantoblancoMadridSpain
  2. 2.Servicio MicrobiologíaHospital Ramón y CajalMadridSpain

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