Advertisement

Archives of gynecology

, Volume 231, Issue 2, pp 149–152 | Cite as

Effect of sulprostone on concentrations of progesterone, 20α-dihydroprogesterone, estrone, and estradiol in human placental tissue in the first trimester of pregnancy

  • T. Laatikainen
  • J. Pelkonen
  • K. Pesonen
  • P. Kajanoja
Original Papers
  • 27 Downloads

Summary

Placentas were obtained from 35 healthy women whose pregnancy was terminated in the first trimester. Seventeen of them had no prostaglandin medication whereas in 18 women 500 μg of sulprostone was administered for cervical softening 12–14 h prior to the termination of pregnancy. Concentrations of progesterone and 20α-dihydroprogesterone were determined from the extract of the placenta by liquid chromatography and those of estrone and estradiol by a radioimmunoassay. Placental progesterone concentration (6,829 ± 469 ng/g wet weight, mean ± SEM) was higher in the sulprostone group than in the control group (5,070 ± 539 ng/g,p < 0.02), but the mean concentrations of 20α-dihydroprogesterone, estrone and estradiol were similar in both groups. Thus the small dose of sulprostone used in this study did not result in any great changes in placental steroidogenesis which could bring about the initiation of abortion. The increase of placental progesterone may, however, indicate that uterine contractions and impaired uteroplacental blood flow secondarily decreased the direct transfer of steroids from the placenta to the myometrium.

Key words

Sulprostone Prostaglandins Placenta Progesterone Estradiol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aleem FA, Schulman H, Saldana LR, Hung HC (1975a) The effect of prostaglandin F on the placental progesterone level in midtrimester abortion. Am J Obstet Gynecol 123: 202–205Google Scholar
  2. Aleem FA, Schulman H (1975b) Midtrimester pregnancy interruption and the placental progesterone levels. Prostaglandins 9: 495–500Google Scholar
  3. Alsat E, Cedard L (1973) The stimulatory action of the prostaglandins on the production of oestrogens by the human placenta perfused in vitro. Prostaglandins 3: 145–153Google Scholar
  4. Gethmann U, Hoppen HO (1977) Hormonkonzentrationen im Plasma und Wehentätigkeit bei Prostaglandin F induziertem Schwangerschaftsabbruch. Arch Gynäkol 224: 269–270Google Scholar
  5. Kajanoja P (1978) Feto-placental hormone profiles during abortion inductions by sulprostone. International Sulprostone Symposium, Vienna, pp 97–99Google Scholar
  6. Laatikainen T, Pesonen K, Pelkonen J (1981) Quantitation of progesterone and 20α-dihydroprogesterone in human placenta and fetal membranes. J Steroid Biochem 14: 519–522Google Scholar
  7. Pulkkinen MO (1978) Pregnancy termination with the PGE2-analogue SHB 286. Prostaglandins 15: 161–167PubMedGoogle Scholar
  8. Pulkkinen MO, Pitkänen Y, Ojala A, Hannelin H (1975) Decrease of utero-placental blood flow during prostaglandin F induced abortion. Prostaglandins 9: 61–66Google Scholar
  9. Rao B (1979) Effect of prostaglandins on in vitro synthesis of progesterone and oestradiol-17β in placenta from early human pregnancy. Prostaglandins 18: 93–100Google Scholar

Copyright information

© J. F. Bergmann Verlag 1982

Authors and Affiliations

  • T. Laatikainen
    • 1
  • J. Pelkonen
    • 1
  • K. Pesonen
    • 1
  • P. Kajanoja
    • 1
  1. 1.Depts. I and II of Obstetrics and GynaecologyUniversity Central HospitalHelsinki 29Finland

Personalised recommendations