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Animal and cell-culture models for the study of mycobacterial infections and treatment

  • Current Topic: Review
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Abstract

Emerging problems with the treatment of infections caused byMycobacterium avium andMycobacterium tuberculosis require the development of new models, both in vitro and in vivo, in which new chemotherapeutic and immunotherapeutic approaches can be tested. In this brief review, the use of cell culture models, in which drugs can be tested for their capacity to inhibit mycobacterial growth within the infected host macrophage, and new models in vivo in which drugs and/or cytokines can be tested in infected mice are discussed. In this latter case, new emerging mouse models include animals with engineered gene disruptions, in which severely disseminated infections can be produced, thus mimicking events in severely immunocompromised human patients.

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Authors and Affiliations

  1. Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, 80523, Fort Collins, Colorado, USA

    I. M. Orme, A. D. Roberts, S. K. Furney & P. S. Skinner

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  1. I. M. Orme
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  2. A. D. Roberts
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  3. S. K. Furney
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  4. P. S. Skinner
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Orme, I.M., Roberts, A.D., Furney, S.K. et al. Animal and cell-culture models for the study of mycobacterial infections and treatment. Eur. J. Clin. Microbiol. Infect. Dis. 13, 994–999 (1994). https://doi.org/10.1007/BF02111500

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