The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs
- 51 Downloads
A new gastric assay was employed to screen for the ulcerogenic activity of non-steroid anti-inflammatory (NSAI) analgesic drugs. The technique involves exposing rats to brief periods of cold stress, which is not itself sufficient to cause mucosal damage, but does specifically sensitize the stomach to irritant or ulcerogenic actions of NSAI drugs. The assessment of gastric ulcerogenicity of some well-known anti-inflammatory/analgesic drugs using this new assay was shown to agree well with clinical reports of the occurrence of gastric ulceration and haemorrhage. This assay was employed to screen for the ulcerogenicity of some new anti-inflammatory drugs and for potential drug interactions resulting from administration of certain frequently used combinations of these drugs.
KeywordsDrug Interaction Gastric Ulceration Cold Stress Potential Drug Clinical Report
Unable to display preview. Download preview PDF.
- K.D. Rainsford,Gastrointestinal and Other Side-Effects from the Use of Aspirin and Related Drugs: Biochemical Studies on the Mechanism of Gastrotoxicity, Agents and Actions, Supplement 1, p. 59 (1977).Google Scholar
- K.D. Rainsford andM.W. Whitehouse.Gastric Mucus Effusion Elicited by Oral Copper Compounds: Potential Anti-Ulcer Activity, Experientia32, 1171–1172 (1976).Google Scholar
- J.C. Bowen andW.H. Fleming,A Prospective Study of Stress Ulceration in Vietnam, Southern Med. J.67, 156–160 (1974).Google Scholar
- K.D. Rainsford,Some Factors Involved in the Synergistic Interaction between Aspirin and Stress which Results in Severe Gastric Mucosal Damage, Clin. exp. Pharmac. Physiol.3, 245–246 (1976).Google Scholar
- K.D. Rainsford,Aspirin and Gastric Ulceration: Light and Electronmicroscopic Observations in a Model of Aspirin plus Stress-Induced Ulcerogenesis, Br. J. exp. Path.58, 215–219 (1977).Google Scholar
- P.M. Brooks, M.A. Bell, R.D. Sturrock, J.P. Famaey andW.C. Dick,The Clinical Significance of Indomethacin-Probenecid Interaction, Br. J. Clin. Pharmac.1, 287 (1974).Google Scholar
- P.M. Brooks, M.A. Bell, D.I. Mason andW.W. Buchanan,Interactions of Anti-Rheumatic Drugs, Agents and Actions, Supplement1 85–95 (1977).Google Scholar
- K.D. Rainsford,The Relationship Between Distribution of Salicylates in the Gastrointestinal Tract and Blood and the Development of Gastric Damage after Oral Administration of Aspirin and Aspirin-Bicarbonate Mixtures in Rats, Clin. exp. Pharmac. Physiol.2, 41 (1975).Google Scholar
- P.M. Brooks andW.W. Buchanan,Current Management of Rheumatoid Arthritis, in:Recent Advances in Rheumatology 1, part 2, (Eds. W.W. Buchanan and W.C. Dick; Churchill Livingstone, Edinburgh, 1976), p. 33.Google Scholar
- J.R. Leonards andG. Levy,Gastrointestinal Blood Loss from Aspirin and Sodium Salicylate Tablets in Man, Clin. Pharm. Ther.14, 62–66 (1973).Google Scholar
- G. Faust, in theInternational Symposium on New Anti-Inflammatory and Anti-rheumatic Drugs (Tirrenia, Italy 1976), Tissue Reactions (in press).Google Scholar