Archives of gynecology

, Volume 231, Issue 3, pp 177–184 | Cite as

Correlations of the receptor content and ultrastructure of breast cancer cells

  • A. H. Tulusan
  • M. Hamann
  • H. Prestele
  • I. Ramming
  • K. von Maillot
  • H. Egger
Original Papers

Summary

Receptor assay results were compared with the ultrastructure of 127 breast cancers (112 primary tumors, six recurrent lesions, nine metastases). Tumors were considered to be receptor positive if the receptor levels were ⩾ 15 fmol/mg of soluble tissue protein. Most breast cancer had heterogenous cells with different grades of ultrastructural differentiation. A prevalence of well-differentiated cancer cells and an abundance of intracytoplasmic vacuoles had a significant correlation with a positive estrogen receptor status. The correlation was better than between malignancy grades and receptor content. The type of breast cancer and the menopausal status bore no relation to receptor content. Progesterone receptors were found in well-differentiated tumors of low malignancy.

Key words

Steroid receptor Ultrastructure Breast cancer 

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Copyright information

© J. F. Bergmann Verlag 1982

Authors and Affiliations

  • A. H. Tulusan
    • 1
  • M. Hamann
    • 1
  • H. Prestele
    • 2
  • I. Ramming
    • 1
  • K. von Maillot
    • 1
  • H. Egger
    • 1
  1. 1.Frauenklinik der Universität Erlangen-Nürnberg (Director: Prof. Dr. K. G. Ober)ErlangenFederal Republic of Germany
  2. 2.Institut für medizinische Statistik und Dokumentation (Chairman: Prof. Dr. L. Horbach)Universität NürnbergNürnbergFederal Republic of Germany

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