Archives of gynecology

, Volume 231, Issue 3, pp 177–184 | Cite as

Correlations of the receptor content and ultrastructure of breast cancer cells

  • A. H. Tulusan
  • M. Hamann
  • H. Prestele
  • I. Ramming
  • K. von Maillot
  • H. Egger
Original Papers


Receptor assay results were compared with the ultrastructure of 127 breast cancers (112 primary tumors, six recurrent lesions, nine metastases). Tumors were considered to be receptor positive if the receptor levels were ⩾ 15 fmol/mg of soluble tissue protein. Most breast cancer had heterogenous cells with different grades of ultrastructural differentiation. A prevalence of well-differentiated cancer cells and an abundance of intracytoplasmic vacuoles had a significant correlation with a positive estrogen receptor status. The correlation was better than between malignancy grades and receptor content. The type of breast cancer and the menopausal status bore no relation to receptor content. Progesterone receptors were found in well-differentiated tumors of low malignancy.

Key words

Steroid receptor Ultrastructure Breast cancer 


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  1. 1.
    Black MM, Speer FD, Opler SR (1956) Structural representation of tumor-host relationships in mammary carcinoma. Biologic and prognostic significance. Am J Clin Pathol 26: 250–265PubMedGoogle Scholar
  2. 2.
    Bloom HJ, Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11: 359–377PubMedGoogle Scholar
  3. 3.
    Fisher ER, Liu CK, Rockette H, Fisher B (1980) Correlation of estrogen receptor and pathologic characteristics of invasive breast cancer. Cancer 45: 349–353PubMedGoogle Scholar
  4. 4.
    Heuson JC, Leclerq G, Lengeval E, Deboel MC, Mettheiem WH, Heimenn R (1975) Estrogen receptors: Prognostic significance in breast cancer. In: McGuire WL, Carbone PP, Vollmer EP (eds) Estrogen receptors in human breast cancer. Raven Press, New York, pp 57–70Google Scholar
  5. 5.
    Jensen EV, Smith S, de Sombre ER (1976) Hormone dependency in breast cancer. J Steroid Biochem 7: 911–917PubMedGoogle Scholar
  6. 6.
    Jungblut PW, Hätzel I, de Sombre ER, Jensen EV (1967) Über Hormon-„Rezeptoren“. Die östrogenbindenden Prinzipien der Erfolgsorgane. 18. Colloquium der Gesellschaft für Physiologische Chemie vom 5. bis 8. April 1967 in Mosbach/Baden. Springer, Berlin Heidelberg New YorkGoogle Scholar
  7. 7.
    Knight WA, Livingston BR, Gregory EJ, McGuire WL (1977) Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res 37: 4669–4671PubMedGoogle Scholar
  8. 8.
    Lesser ML, Rosen PP, Senie RT, Duthie K, Menendez-Botet C, Schwartz M (1981) Estrogen and progesterone receptors in breast carcinoma: Correlations with epidemiology and pathology. Cancer 48: 299–309PubMedGoogle Scholar
  9. 9.
    Maillot K von, Egger H, Horke W, Prestele H (subm. for public.) Die Korrelation des Steroidrezeptorstatus zu histomorphologischen Kriterien und der Prognose des operierten Mammacarcinoms. Arch GynecolGoogle Scholar
  10. 10.
    Maillot K von, Gentsch HH, Gunselmann W (1980) Steroid receptors and response to endocrine treatment and chemotherapy of advanced breast cancer. J Cancer Res Clin Oncol 98: 301–313PubMedGoogle Scholar
  11. 11.
    Maillot K von, Horke W, Prestele H (1982) Prognostic significance of the steroid receptor content in primary breast cancer. Arch Gynecol 231: 1852–190Google Scholar
  12. 12.
    Maas H, Engel B, Trams G (1975) Steroid hormone receptors in human breast cancer and the clinical significance. J Steroid Biochem 6: 743–749PubMedGoogle Scholar
  13. 13.
    McGuire WL, Carbone PP, Sears ME, Escher GC (1974) Estrogen receptors in human breast cancer. An overview. In: McGuire WL, Carbone PP, Vollmer EP (eds) Estrogen receptors in human breast cancer. Raven Press, New York, pp 1–7Google Scholar
  14. 14.
    Rosen PP, Menendez-Botet CJ, Senie RT, Schwartz MK, Schottenfeld D, Farr GH (1978) Estrogen receptor protein and the histopathology of human mammary carcinoma. In: McGuire WL (ed) Hormones, receptors and breast cancer. New York, Raven Press, pp 71–83Google Scholar
  15. 15.
    Stegner HE, Trams G, Pape C (1980) Estrogen receptors and ultrastructural pathology of mammary carcinoma. In: Dallenbach-Hellweg G (ed) Functional morphologic changes in female sex organs induced by exogenous hormones. Springer, Berlin Heidelberg New York, pp 221–228Google Scholar
  16. 16.
    Walker RA, Cove DH, Howell A (1980) Histological detection of estrogen receptor in human breast carcinomas. Lancet 1: 171–173PubMedGoogle Scholar

Copyright information

© J. F. Bergmann Verlag 1982

Authors and Affiliations

  • A. H. Tulusan
    • 1
  • M. Hamann
    • 1
  • H. Prestele
    • 2
  • I. Ramming
    • 1
  • K. von Maillot
    • 1
  • H. Egger
    • 1
  1. 1.Frauenklinik der Universität Erlangen-Nürnberg (Director: Prof. Dr. K. G. Ober)ErlangenFederal Republic of Germany
  2. 2.Institut für medizinische Statistik und Dokumentation (Chairman: Prof. Dr. L. Horbach)Universität NürnbergNürnbergFederal Republic of Germany

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