Ectopic production of placenta-“specific” tissue proteins (PP5 and PP11) by malignant breast tumors
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With use of an enzyme-bridge immunoperoxidase (PAP) technique, an immunohistochemical localization of the two new placenta-“specific” tissue proteins, PP5 and PP11, was investigated in 16 cases of breast cancer. PP5 was localized in the cytoplasm of breast cancer cells in 62.5% of cases examined and PP11, in 46.7%.
Thus PP5 and PP11 may be markers for breast cancer and the detection of these proteins in sera from breast cancer patients may be more reliable and useful in the detection and monitoring of breast cancer patients than the determination of SP1, PP10, or PP12, other pregnancy “specific” proteins.
Key wordsPlacental specific tissue proteins (PP5, PP11) Immunohistochemical localization Enzyme-bridge immunoperoxidase technique Malignant breast tumors
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- 1.Bohn H (1980) New placental and pregnancy proteins as possible markers in oncology. Klin Wochenschr 58: 489–492Google Scholar
- 2.Bohn H, Kraus W (1979) Isolierung und Charakterisierung eines neuen plazenta-spezifischen Proteins (PP10). Arch Gynecol 227: 125–134Google Scholar
- 3.Bohn H, Kraus W (1980a) Isolierung und Charakterisierung eines neuen plazenta-spezifischen Proteins (PP12). Arch Gynecol 229: 279–291Google Scholar
- 4.Bohn H, Winckler W (1977) Isolierung und Charakterisierung des Plazenta-Proteins PP5. Arch Gynecol 223: 179–186Google Scholar
- 5.Bohn H, Winckler W (1980) Isolierung und Charakterisierung eines neuen Plazenta-Gewebeproteins (PP11). Arch Gynecol 229: 293–301Google Scholar
- 6.Bohn H, Inaba N, Lüben G (1981) New placental proteins and their potential diagnostic significance as tumor markers. Oncodevelopmental Biology and Medicine (in press) Biomedical Press, Elsevier/North-HollandGoogle Scholar
- 7.Burn J (1975) Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry 43: 291–294Google Scholar
- 8.Bremner RD, Nisbet AD, Herriot R, Horne CHW, McArdle C, Crawford D, Bohn H (1981) Detection of placental protein five (PP5) and pregnancy-specific glycoprotein (SP1) in benign and malignant breast disease. Oncodevelopmental Biology and Medicine 2: 55–62Google Scholar
- 9.Horne CHW, Reid IN, Milne GD (1976) Prognostic significance of inappropriate production of pregnancy proteins by breast cancer. Lancet 2: 279–282Google Scholar
- 10.Inaba N, Renk T, Bohn H (1980) Immunohistochemical location of placental proteins (PP8, 9, 10, 11, 12) in human term placentae. Arch Gynecol 230: 109–121Google Scholar
- 11.Inaba N, Renk T, Weinmann E, Bohn H (1981) Immunohistochemical location of proteins related to pregnancy-specific β1-glycoprotein (SP1) and placental tissue proteins (PP5, PP8, PP9, PP10, PP11, PP12) in the afterbirth of cynomolgus monkeys (Macaca fascicularis). Arch Gynecol 230: 195–204Google Scholar
- 12.Inaba N, Renk T, Wurster K, Rapp W, Bohn H (1980) Ectopic synthesis of pregnancy specific β1-glycoprotein (SP1) and placental specific tissue proteins (PP5, PP10, PP11, PP12) in nontrophoblastic malignant tumors. Possible markers in oncology. Klin Wochenschr 58: 789–791Google Scholar
- 13.Inaba N, Renk T, Ax W, Weinmann E, Schottler S, Bohn H (1981) Possible synthesis of pregnancy-specific β1-glycoprotein (SP1) and placenta-specific tissue proteins (PP10, PP12) by human and cynomolgus monkey (Macaca fascicularis) leukocytes. Acta Haematol 66: 35–38Google Scholar
- 14.Mason TA, Phifer RF, Spicer SS, Swallow RA, Dreskin RB (1969) An immunoglobulin enzyme bridge method for localizing tissue antigens. J Histochem Cytochem 17: 563–569Google Scholar
- 15.Rosen SW, Javadpour N, Calvert I, Kaminska J (1979) Increased “pregnancy-specific” beta1-glycoprotein in certain nonseminomatous germ cell tumors. J Natl Cancer Inst 62: 1439–1441Google Scholar
- 16.Sedlacek HH, Rehkopf R, Bohn H (1976) Immunofluorescence histological localization of human pregnancy and placenta proteins in the placenta of man and monkey (Cynomolgus). Behring Inst Mitt 59: 81–91Google Scholar
- 17.Wurster K, Kuhlman WD, Rapp W (1978) Immunohistochemical studies on human gastric mucosa. Procedures for routine demonstration of gastric proteins by immunoenzyme techniques. Virchows Arch [Pathol Anat] 328: 213–228Google Scholar