Archives of gynecology

, Volume 231, Issue 1, pp 87–90 | Cite as

Ectopic production of placenta-“specific” tissue proteins (PP5 and PP11) by malignant breast tumors

  • N. Inaba
  • T. Renk
  • E. Daume
  • H. Bohn


With use of an enzyme-bridge immunoperoxidase (PAP) technique, an immunohistochemical localization of the two new placenta-“specific” tissue proteins, PP5 and PP11, was investigated in 16 cases of breast cancer. PP5 was localized in the cytoplasm of breast cancer cells in 62.5% of cases examined and PP11, in 46.7%.

Thus PP5 and PP11 may be markers for breast cancer and the detection of these proteins in sera from breast cancer patients may be more reliable and useful in the detection and monitoring of breast cancer patients than the determination of SP1, PP10, or PP12, other pregnancy “specific” proteins.

Key words

Placental specific tissue proteins (PP5, PP11Immunohistochemical localization Enzyme-bridge immunoperoxidase technique Malignant breast tumors 


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Copyright information

© J. F. Bergmann Verlag GmbH & Co. KG München 1981

Authors and Affiliations

  • N. Inaba
    • 1
  • T. Renk
    • 1
  • E. Daume
    • 2
  • H. Bohn
    • 1
  1. 1.Research LaboratoriesBehringwerke AGMarburg (Lahn)Federal Republic of Germany
  2. 2.Dept. of Gynecology and ObstetricsPhilipps UniversityMarburg (Lahn)Federal Republic of Germany

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