Summary
The increase in the number of the ovarian LH/HCG-receptors and the rise in serum progesterone concentration during pregnancy in the rat depend on the presence of prolactin during the process of luteinization. Blocking of the hypophyseal prolactin secretion in rats by twice daily injections of 2 μg/g of body weight of bromocriptine from the first day of pregnancy onwards prevents the increase in ovarian HCG-binding, progesterone production, and the implantation of blastocysts. The lack of implantation is not due to a teratogenic effect of bromocriptine but is due to deficient decidual changes caused by a lack of progesterone production by luteal cells.
Zusammenfassung
Die Zunahme der ovariellen LH/HCG-Rezeptorzahl und der Serum-Progesteronspiegel während der Schwangerschaft bei der Ratte beruht auf der Wirkung von Prolaktin während der Luteinisierungsphase. Wird die hypophysare Prolaktinsekretion durch die täglich zweimalige Gabe von 2 μg/g Körpergewicht Bromocriptin vom ersten Tag der Schwangerschaft an geblockt, so bleibt die Zunahme an HCG-Bindungsstellen aus, die Progesteronproduktion ist vermindert und eine Implantation von Blastocysten findet nicht statt. Das Ausbleiben der Implantation beruht nicht auf einem teratogenen Effekt von Bromocriptin auf präimplantive Eistadien, sondern auf der mangelnden sekretorischen Umwandlung des Endometriums aufgrund der fehlenden Progesteronproduktion im Corpus luteum.
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Diese Arbeit wurde gefördert von der Deutschen Forschungsgemeinschaft (Si 185/2)
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Siebers, J.W., Müller, U. Hemmung der Implantation bei der Ratte durch Bromocriptin. Arch. Gynecol. 229, 77–81 (1980). https://doi.org/10.1007/BF02109830
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DOI: https://doi.org/10.1007/BF02109830