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Archives of gynecology

, Volume 229, Issue 4, pp 325–331 | Cite as

Tumour markers with unknown functions in gynaecological neoplasia

  • M. R. Price
  • P. J. McLaughlin
  • R. A. Robins
  • R. W. Baldwin
  • D. Vasey
  • E. M. Symonds
Article

Summary

Pre- and post-operative ovarian cancer patients' sera were examined for the presence or circulating immune complexes using a variety of assay procedures. In contrast to findings with breast cancer patients' sera, sera from patients with other gynaecological tumours or with preclinical disease diagnosed by cytology, no evidence was obtained to indicate that circulating immune complexes were associated with ovarian cancer.

Key words

Immune complexes Gynaecological neoplasia 

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References

  1. Agnello V, Winchester RJ, Kunkel HG (1970) Precipitin reactions of the Clq component of complement with aggregated γ-globulin and immune complexes in gel diffusion. Immunology 19: 909–919PubMedGoogle Scholar
  2. Baldwin RW, Price MR, Robins RA (1972) Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumourspecific antigen-antibody complexes. Nature New Biol 238: 185–187CrossRefPubMedGoogle Scholar
  3. Baldwin RW, Bowen JG, Price MR (1973) Detection of circulating hepatoma D23 antigen and immune complexes in tumour bearer serum. Br J Cancer 28: 16–24PubMedGoogle Scholar
  4. Baldwin RW, Embleton MJ, Price MR, Vose BM (1974) Embryonic antigen expression on experimental rat tumours. Transplant Rev 20: 77–99PubMedGoogle Scholar
  5. Bowen JG, Baldwin RW (1976) Isolation and characterization of tumour-specific antigen from serum of rats bearing transplanted aminoazo dye-induced hepatomas. Transplantation 21: 213–219PubMedGoogle Scholar
  6. Coggin J, Anderson NG (1974) Cancer differentiation, and embryonic antigens: Some central problems. Adv Cancer Res 19: 106–166Google Scholar
  7. Disaia PJ (1976) Overview of tumor immunology in gynecologic oncology. Cancer 38: 566–580PubMedGoogle Scholar
  8. Evans WH (1976) The liver plasma membrane as a functional mosaic. Biochem Soc Trans 4: 1007–1011PubMedGoogle Scholar
  9. Fletcher DS, Lin TY (1977) Quantitation of immune complexes by competitive inhibition of Clq to insoluble IgG aggregates. J Immunol Meth 15: 39–45CrossRefGoogle Scholar
  10. Höffken K, Meredith ID, Robins RA, Baldwin RW, Davies CJ, Blamey RW (1977a) Circulating immune complexes in breast cancer patients. Br Med J 2: 218–220Google Scholar
  11. Höffken K, Price MR, McLaughlin PJ, Moore V, Baldwin RW (1977b) Circulating immune complexes in rats bearing chemically induced tumours. I. Sequential determination during the growth of tumours at various body sites. Int J Cancer 21: 496–504Google Scholar
  12. Höffken K, Meredith ID, Robins RA, Baldwin RW, Davies CJ, Blamey RW (1978a) Immune complexes and prognosis of human breast cancer. Lancet 1: 672CrossRefGoogle Scholar
  13. Höffken K, Price MR, Moore V, Baldwin RW (1978b) Circulating immune complexes in rats bearing chemically-induced tumours: II. Characterisation of sera from different stages of tumour growth. Int J Cancer 22: 576Google Scholar
  14. Lancet (Editorial) (1977) Immune complexes in health and disease. Lancet 1: 580PubMedGoogle Scholar
  15. Nicolson GL, Poste G (1976a) The cancer cell: Dynamic aspects and modifications in cell-surface organization (Part 2). New Engl J Med 295: 253–258Google Scholar
  16. Nicolson GL, Poste G (1976b) The cancer cell: dynamic aspects and modifications in cell-surface organization (Part 1). New Engl J Med 295: 197–203Google Scholar
  17. Papsidero LD, Harvey SR, Snyderman MC, Nemoto T, Valenzuela L, Chu TM (1978) Characterization of immune complexes from the pleural effusion of a breast cancer patients. Int J Cancer 21: 675–682PubMedGoogle Scholar
  18. Poulton TA, Crowther ME, Hay FC, Nineham LJ (1978) Immune complexes in ovarian cancer. Lancet 2: 72CrossRefPubMedGoogle Scholar
  19. Price MR, Baldwin RW (1977) Shedding of tumor cell surface antigens. In: Poste G, Nicolson GL (eds) Dynamic aspects of cell surface organization. Cell surface reviews, vol 3. North Holland, Amsterdam, p 423–471Google Scholar
  20. Price MR, Robins RA (1978) Circulating factors modifying cell-mediated immunity in experimental neoplasia. In: Castro JE (ed) Immunological aspects of cancer. MTP Press, Lancaster, p 155–181Google Scholar
  21. Rees RC, Price MR, Baldwin RW (1979) Expression of oncodevelopmental antigens in chemical carcinogenesis. In: Busch H (ed) Methods in cancer research, vol 15. Academic Press, New York (in press), pp 99–133Google Scholar
  22. Robins RA, Baldwin RW (1977) Immune markers on cancer cells. Cancer Immunol Immunotherap 2: 205–209Google Scholar
  23. Robins RA, Baldwin RW (1978) Immune complexes in cancer. Cancer Immunol Immunother 4: 1–3CrossRefGoogle Scholar
  24. Rossen RD, Reisberg MA, Hersh EM, Gutterman JU (1977) The Clq binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst 58: 1205–1215PubMedGoogle Scholar
  25. Sjögren HO, Hellström I, Bansal SC, Hellström KE (1971) Suggestive evidence that the “blocking antibodies” of tumor bearing individuals may be antigen-antibody complexes. Proc Natl Acad Sci 68: 1372–1375PubMedGoogle Scholar
  26. Teshima H, Wanebo H, Pinsky C, Day NK (1977) Circulating immune complexes detected by the125I-Clq deviation test in sera of cancer patients. J Clin Invest 59: 1134–1142PubMedGoogle Scholar
  27. Theofilopoulos AN, Wilson CB, Dixon FJ (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57: 169–182PubMedGoogle Scholar
  28. Theofilopoulos AN, Andrews BS, Urist MH, Morton DL, Dixon FJ (1977) The nature of immune complexes in human cancer sera. J Immunol 119: 657–663PubMedGoogle Scholar
  29. Wisher MH, Evans WH (1975) Functional polarity of the rat hepatocyte surface membrane. Biochem J 146: 375–388PubMedGoogle Scholar
  30. Yamada K (1978) Cell surface marker for malignancy. Nature (Lond) 273: 335CrossRefGoogle Scholar
  31. Zubler RH, Lambert PH (1976) The125I-Clq binding test for the detection of soluble immune complexes. In: Bloom BR, Davids JR (eds) In vitro methods in cell-mediated and tumour immunity. Academic Press, New York, pp 565–572Google Scholar

Copyright information

© J. F. Bergmann Verlag 1980

Authors and Affiliations

  • M. R. Price
    • 1
  • P. J. McLaughlin
    • 1
  • R. A. Robins
    • 1
  • R. W. Baldwin
    • 1
  • D. Vasey
    • 2
  • E. M. Symonds
    • 2
  1. 1.Cancer Research Campaign LaboratoriesUniversity of Nottingham, City HospitalNottinghamUK
  2. 2.Department of Obstetrics and GynaecologyCity HospitalNottinghamUK

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