Zusammenfassung
Im Ovar schwankt die Zahl der LH/HCG-Rezeptoren während des Zyklus. Die meisten freien Rezeptoren lassen sich im Diöstrus II nachweisen, während Ovarien im Östrus nur sehr wenig125I-HCG binden. Bromocriptin, ein Inhibitor der Prolaktinsekretion, unterdrückt die zyklischen Schwankungen freier LH/HCG-Rezeptoren. Daraus wird gefolgert, daß LH/HCG-Rezeptoren des Corpus luteum im Zyklus nur einmal mit LH besetzt und danach abgebaut werden. Die Oszillation freier Rezeptoren kommt ausschließlich durch Synthese und Abbau von Rezeptoren der Lutealzellen zustande.
Summary
The number of LH/HCG receptors varied during the ovarian cycle. Most125I-HCG was bound in the diestrous II stage, least amounts of free binding sites were detectable in estrous. Bromocriptine, an inhibitor of prolactin secretion, suppressed the cyclic variations in free LH/HCG receptors. From this finding it is concluded that LH/HCG receptors of the corpus luteum of the cycle are occupied by LH just once and then degraded. The variations in the number of free LH/HCG receptors are probably due to the synthesis and degradation of only luteal receptors.
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This work was supported by the Deutsche Forschungsgemeinschaft (Si 185/4)
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Müller, U., Bauknecht, T. & Siebers, J.W. Regulation of LH/HCG receptors during the ovarian cycle in rats. Arch. Gynecol. 230, 137–142 (1980). https://doi.org/10.1007/BF02108268
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DOI: https://doi.org/10.1007/BF02108268