Osteoporosis International

, Volume 5, Issue 3, pp 156–160 | Cite as

Bone loss in patients with inflammatory bowel disease: A prospective study

  • C. Roux
  • V. Abitbol
  • S. Chaussade
  • S. Kolta
  • S. Guillemant
  • M. Dougados
  • B. Amor
  • D. Couturier
Original Article


To assess the rate of bone loss in patients with inflammatory bowel disease, we prospectively studied 35 patients (17 women) aged 36±13 (range 17–60) years, 14 of whom had Crohn's disease and 21 with ulcerative colitis (including 12 with ileoanal anastomosis). Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck. The follow-up was 19±8 months. During this period, 14 patients received oral steroids. Lumbar bone density changes expressed as a percentage per year were −3.1±4.9%, −6.4±7.5% and +2.0±4.0% in Crohn's disease and ulcerative colitis without and with ileoanal anastomosis respectively (p=0.007). The same pattern was observed at the femoral neck. Mean annual lumbar bone density changes were −6.2±7.0% and +0.9±3.9% in patients with and without steroids during follow-up (p=0.002). We conclude that patients with inflammatory bowel disease are at risk of lumbar and femoral bone loss. However, bone loss is not observed in patients with ileoanal anastomosis.


Bone mineral density Ileoanal anastomosis Inflammatory bowel disease Osteoporosis 


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Copyright information

© European Foundation for Osteoporosis 1995

Authors and Affiliations

  • C. Roux
    • 1
  • V. Abitbol
    • 2
  • S. Chaussade
    • 2
  • S. Kolta
    • 1
  • S. Guillemant
    • 3
  • M. Dougados
    • 1
  • B. Amor
    • 1
  • D. Couturier
    • 2
  1. 1.Clinique de Rhumatologie, Hôpital CochinUniveristé René DescartesParisFrance
  2. 2.Service d'Hépato-Gastro-Entérologie, Hôpital CochinUniversité René DescartesParisFrance
  3. 3.Laboratoire de BiochimieUniversité Pierre et Marie CurieParisFrance

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