Journal of Traumatic Stress

, Volume 9, Issue 4, pp 857–863 | Cite as

The use of anticonvulsants in posttraumatic stress disorder: Case study and overview

  • Nicholas Ford
Brief Report


A case of posttraumatic stress disorder is described in which a favorable response to the anticonvulsants carbemazepine and sodium valproate occurred. The literature on the use of anticonvulsants in this disorder is reviewed.

Key words

carbemazepine sodium valproate posttraumatic stress disorder 


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  1. American Psychiatric Association (1994). Practice guide-lines for the treatment of patients with bipolar disorder.American Journal of Psychiatry 151(Suppl.), 5–14.Google Scholar
  2. Archibald, H., & Tuddenham, R. (1965). Persistent stress reactions after combat: A 20 year follow up.Archives of General Psychiatry, 22 475–481.Google Scholar
  3. Friedman, M. (1988) Toward rational pharmacotherapy for post traumatic stress disorder.American Journal of Psychiatry, 145 281–285.PubMedGoogle Scholar
  4. Fesler, F. (1991). Valproate in combat related post traumatic stress disorder.Journal of Clinical Psychiatry, 52 361–364.PubMedGoogle Scholar
  5. Horowitz, M., Wilner, N., & Kaltreider, N. (1980). Signs and symptoms of post traumatic stress disorder.Archives of General Psychiatry, 37 85–92.PubMedGoogle Scholar
  6. Keck, P., McElroy, M., & Friedman, L. (1992). Valproate and carbemazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states and behavioural dyscontrol syndromes.Journal of Clinical Psychopharmacology, 12(Suppl. 1), 36–41.Google Scholar
  7. Klein, E. Colin, E., Stolk, J., & Lenox R. (1994). Alprazolam withdrawal in patients with panic and generalized anxiety disorder: Vulnerability, and effect of carbemazepine.American Journal of Psychiatry, 151 1760–1765.PubMedGoogle Scholar
  8. Lipper, S., Davidson, J., Grady, T., Edinger, J., Hammett, E., Mahorney, S., & Cavenar, J. (1986). Preliminary study of carbemazepine in post traumatic stress disorder.Psychosomatics, 27 849–853.PubMedGoogle Scholar
  9. McFarlane A., & Papay P. (1992). Multiple diagnoses in post traumatic stress disorder in the victims of a natural disaster.Journal of Nervous and Mental Disease, 180 498–504.PubMedGoogle Scholar
  10. Post, R., Weiss, S., & Chuang, D. (1992). Mechanisms of action of anticonvulsants in affective disorders.Journal of Clinical Psychopharmacology, 12(Suppl. 1), 23–35.Google Scholar
  11. Rall, T., & Schleiffer, L. (1990). Drugs effective in the epilepsies. In A. G. Gilman, T. W. Rall, A. S. Nies, & P. Taylor (Eds.)The pharmacological basis of therapeutics (pp. 436–462). New York: Pergamon.Google Scholar
  12. Schweitzer, E., Rickels, K., Case, W., & Greenblatt, D. (1991). Carbemazepine treatment in patients discontinuing long term benzodiazepine treatment.Archives of General Psychiatry, 48 448–452.PubMedGoogle Scholar
  13. Silver, J., Sandberg, D., & Hales, R. (1990). New approaches in the pharmacology of posttraumatic stress disorder.Journal of Clinical Psychiatry, 51(Suppl. 10), 33–38.Google Scholar
  14. Southwick, S., Bremner, D., Krystal, J., & Charney, D. (1994). Psychobiologic research in PTSD.Psychiatric Clinics of North America, 17(2), 409–423.PubMedGoogle Scholar
  15. Sutherland, S., & Davidson, J. (1994). Pharmacotherapy for posttraumatic stress disorder.Psychiatric Clinics of North America, 17(2), 409–423.PubMedGoogle Scholar
  16. van der Kolk, B., Greenberg, M., & Boyd, H. (1985). Inescapable shock, neurotransmitters and addiction to trauma: Toward a psychobiology of Posttraumatic stress.Biological Psychiatry, 20 314–325.CrossRefPubMedGoogle Scholar
  17. Wolff, M., Alavi, A., & Mosnaim, A. S. (1988). PTSD in Vietnam veterans. Clinical and EEG findings: Possible therapeutic effects of carbemazepine.Biological Psychiatry, 23 642–644.CrossRefPubMedGoogle Scholar

Copyright information

© International Society for Traumatic Stress Studies 1996

Authors and Affiliations

  • Nicholas Ford
    • 1
  1. 1.AdelaideAustralia

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